Dermatomyositis (DM) is a chronic, systemic autoimmune disease affecting the skin, muscle, and lungs. Lenabasum, non-psychoactive cannabinoid type 2 receptor (CB2R) agonist, currently being investigated as non-immunosuppressive treatment option for DM. The activation of CB2R has been shown to reduce several key pro-inflammatory cytokines implicated in Our lab previously demonstrated via immunoh...

Background and objectives The relationship between the tumor microenvironment network of key signaling pathways in cancer plays a role occurrence development tumors. Tumor-associated macrophages (TAMs) are important inflammatory cells play an tumorigenesis progression. Macrophages malignant tumors, mainly M2 subtype, promote progression by producing cytokines down-regulating anti-inflammatory i...

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease caused by the immune-mediated reduction of β cells, resulting in lifelong dependence on exogenous insulin administration. We studied impact M1/M2 macrophages cell level. obtained healthy state (absence T1D) and unhealthy (presence T1D). found that state, levels are decreased with continuous alternative switch between M1 M2 macrophag...

Macrophages have been confirmed to play a significant role in the behavior of human lymphomas, albeit no consistent data are so far available canine lymphomas. The present study characterizes macrophages cases nodal lymphoma and their relationship with histological grade immunophenotype. Samples from lymph nodes 25 dogs diagnosed were selected. Immunohistochemistry was used determine tumor immu...

Microorganisms such as bacteria that penetrate the epithelial surfaces of body for first time are met immediately by cells and molecules can mount an innate immune response. Phagocytic macrophages conduct defense against means surface receptors able to recognize bind common constituents many bacterial surfaces. Bacterial binding these trigger macrophage engulf bacterium also induce secretion bi...

recent studies have established that sex hormones directly or indirectly affect t and b cells and macrophages by manipulating the production of cytokines. in this study the possibility of the effect of 5a-dht on macrophage (mφ) nitric oxide (no) release via interleukin-l, 6 (ll-1β, il-6) or tumor necrosis factor-a (tnfα) was investigated. the endogenous cytokines il-1β, il-6 and tnf-α were neut...

background & objectives: chronicity of lupus nephritis (ln) should be considered for interaction of cell mediated immunity (cmi) and dendritic cells in glomeruli and tubulointerstitial areas. in this study establishment of immunohistopathological changes of dendritic cells and other immune effector cells in lupus nephritis comparing with non-lupus nephritis was performed. materials & m...

Macrophages are responsible for removing the extravasated blood that forms a bruise. Aspects of this process, such as how long it takes erythrocytes to be phagocytosed and iron demonstrated using Perls stain, not established. This work sought assess possibility macrophages in cell culture address some unknowns processes resolution Human peripheral monocytes were obtained from buffy coats provid...

FAO estimates that in 2030 the poultry meat production could reach 120 million tons, which is a challenge terms of waste management. Feathers are mainly composed keratin, an important biomaterial. Using feathers as source keratin will minimize generated, while contributing to supply material for several industries, such pharmaceutical and biomedical. The peptides were extracted from by microbia...

Regulation of cellular metabolism is now recognized as a crucial mechanism for the activation innate and adaptive immune cells upon diverse extracellular stimuli. Macrophages, instance, increase glycolysis stimulation with pathogen-associated molecular patterns (PAMPs). Conceivably, pathogens also counteract these metabolic changes their own survival in host. Despite this dynamic interplay host...