BACKGROUND Long-term trials are needed to capture information regarding the persistence of efficacy and loss to follow-up of both mandibular advancement device (MAD) therapy and continuous positive airway pressure (CPAP) therapy. OBJECTIVES The aim of the study was to compare these treatment aspects between MAD and nasal CPAP (nCPAP) in a 1-year follow-up. METHODS Forty-three mild/moderate ...

The purpose of this article is to review 1) mandibular advancement device (MAD) - indication, treatment success, and side effects; 2) maxillomandibular advancement (MMA) surgery of the jaws - indication, treatment success, and side effects; and 3) current perspectives. Both MAD and MMA are administered to increase the upper airway volume and reduce the collapsibility of the upper airway. MAD is...

Decapentaplegic (Dpp), a member of the TGF-beta family of cytokines, has been implicated in many patterning processes in Drosophila, including the initial steps of pattern formation in the developing eye. We show that the Mothers against dpp (Mad) gene is required for dpp signaling during eye development. Clonal analysis demonstrates a cell-autonomous function for Mad and genetic interactions i...

Although most theories of choice are cognitive, recent research has emphasized the role of emotions. We used a novel context--the Mad Cow crisis in France--to investigate how emotions alter choice even when consequences are held constant. A field study showed that individuals reduced beef consumption in months after many newspaper articles featured the emotional label "Mad Cow," but beef consum...

In this work, we report a novel design of a passively controlled, finger-driven microfluidic circuit for the metering and delivery (MaD) of a liquid reagent. The proposed design modularized the fluidic circuit for a single reagent's MaD so that it can be multiplexed conveniently for the MaD of an arbitrary number of reagents solely by finger pressing. The microdevice has comparable accuracy wit...

OBJECTIVE To determine the predictors affecting treatment outcome after application of the mandibular advancement device (MAD). DESIGN Retrospective analysis. SETTING Tertiary care university hospital. PATIENTS A total of 76 patients (68 men and 8 women) who were treated with the MAD for obstructive sleep apnea (OSA) were included from September 2005 through August 2008. All the subjects ...

BACKGROUND Budesonide is a potent corticosteroid commonly prescribed for management of inflammation in chronic rhinosinusitis (CRS). The standard for prescribing budesonide is via impregnated nasal saline irrigation (INSI), although recently the mucosal atomization device (MAD) has emerged as a theoretically superior method of distributing medication into the sinuses. The MAD atomizes medicatio...

BACKGROUND Human immunodeficiency virus (HIV) and methamphetamine use commonly affect neurocognitive (NC) functioning. We evaluated the relationships between NC functioning and two fibroblast growth factors (FGFs) in volunteers who differed in HIV serostatus and methamphetamine dependence (MAD). METHODS A total of 100 volunteers were categorized into four groups based on HIV serostatus and MA...

Components of the signaling pathways that lie downstream of Ser/Thr kinase receptors and are required for signaling by the TGF beta superfamily have been poorly defined. The Drosophila gene Mothers against dpp (MAD) and the C. elegans sma genes are implicated in these signaling pathways. We show that MAD functions downstream of DPP receptors and is required for receptor signaling. Phosphorylati...

Computerized generation of humor is a notoriously difficult AI problem. We develop an algorithm called Libitum that helps humans generate humor in a Mad Lib R ©, which is a popular fill-in-the-blank game. The algorithm is based on a machine learned classifier that determines whether a potential fill-in word is funny in the context of the Mad Lib story. We use Amazon Mechanical Turk to create gr...