Background Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A. Objectives To report Week (Wk) 0–16 safety of BKZ and placebo (PBO) 2 axial spondyloarthritis (axSpA) psoriatic arthritis (PsA) phase 3 studies. Methods Patients (pts) pools received ≥1 dose subcutaneous 160 mg or PBO every 4 wks during Wks (double-blind phase) BE MOB...

Background: The COVID-19 pandemic has impacted health, lifestyle, treatment and healthcare of European patients with rheumatic musculoskeletal diseases (RMDs). Objectives: aim is to evaluate gender differences on the impact first wave in wellbeing, life habits, treatment, access RMDs. Methods: REUMAVID an international collaboration led by Health & Territory Research at University Seville, ...

Purpose: Acoustic noise during the operation of an MR scanner causes discomfort for both patients and technicians. On the other hand, people routinely pay money to hear live music concerts that are significantly louder than an MRI scan. Thus it is largely the unpleasant “banging” sound that is the problem, and not necessarily the volume. The goal of this study is take advantage of the additiona...

Human society has found the means to collect and store vast amounts of information about every subject imaginable, and is archiving this information in attempts to use it for scientific, utilitarian (e.g., health), and business purposes. These large databases are colloquially termed Big Data. How big BigData are is of course a matter of perspective, and can range, for example, from the “tiny” a...

Class III alcohol dehydrogenase (ADH3), also termed formaldehyde dehydrogenase or S-nitrosoglutathione reductase, plays a critical role in the enzymatic oxidation of formaldehyde and reduction of nitrosothiols that regulate bronchial tone. Considering reported associations between formaldehyde vapor exposure and childhood asthma risk, and thus potential involvement of ADH3, we reviewed the onto...

s from the 16th Annual International Symposium on Man and His Environment in Health and Disease 1998 The 1998 Annual International Symposium focused on the environmental aspects of endocrinology with an emphasis on estrogen mimics. This conference explored some of the latest data and provided a forum for discussion as well as case studies to help the professional. "Allergy Patients with Autoimm...

Images rendered using global illumination algorithms are considered amongst the most realistic in 3D computer graphics. However this high fidelity comes at significant computational expense. It has long been a goal of computer graphics to create realistic images at an interactive rate, unfortunately the computational cost of these algorithms prohibits this. As a direct result of this, the ‘real...

Blast, Magnaporthe oryzae B. Couch, and sheath blight, Rhizoctonia solani Kühn, are major fungal diseases of cultivated rice (Oryza sativa L.) in theUSA. Resistance toU.S.M. oryzae races was observed in 91 newly introduced rice accessions, suggesting these accessions are possible sources of novel blast resistance genes (Pi-genes) that could be incorporated into U.S. rice cultivars. The genes Pi...

UNDERSTANDING AND ENGINEERING THE COLLAGEN TRIPLE HELIX Matthew Donald Shoulders Under the supervision of Professor Ronald T. Raines At the University of Wisconsin-Madison This thesis presents a hypothesis-driven approach to collagen research that integrates the power of organic chemistry with the tools of biophysics to enhance our understanding of proline conformation and collagen structure an...

People express their mental states all the time, even when interacting with machines. These mental states shape the decisions that we make, govern how we communicate with others, and affect our performance. The ability to attribute mental states to others from their behaviour, and to use that knowledge to guide one’s own actions and predict those of others is known as theory of mind or mind-rea...