introduction: depression is a mental disorder that highly associated with immune system. therefore, this study compares the serum concentrations of il-21, il-17, and transforming growth factor β (tgf-β) between patients with major depressive disorder and healthy controls. methods: blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls wi...

AIM The aim of this report is to present the management of the maxillary deformity and subsequent implant therapy of a case with β-thalassemia major. BACKGROUND β-thalassemia is a hematologic disorder that results from the abnormality of the β-globulin chain synthesis. The best known thalassemia-induced dentofacial problem is the maxillary enlargement, and this undesirable growth of maxilla a...

During recent years, there was growing demand in using microalga valuable products such as β-carotene in health care. β-Carotene has anti-cancer and anti-aging properties for human. In Dunaliella salina cells, β-carotene has a major protecting role for biomolecules, when the production of reactive oxygen species elevated. In the present study, we investigated the influence of the four most effe...

The chemical composition of plant polyphenols Plantago major L. and lanceolata growing in Uzbekistan was studied. More than 20 compounds, including 7 flavonoids, 9 phenolic acids, 8 hydrolysable tannins, the ages which have been determined using physicochemical methods research isolated from plants. From P. L., along with well-known such as gallic acid, rutin, luteolin, isorhamnetin, hyperoside...

Chronic blood transfusion is the only treatment for severe anemia in patients with β-thalassemia major. However, red blood cell transfusions lead to iron overload and subsequent organ damage because of the toxic effects of iron. The heart is particularly vulnerable to iron toxicity, and heart failure is the leading cause of death among these patients. Iron chelation therapy prevents or reverses...

Zymosan is a beta-glucan- and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses effected by phagocytes. The macrophage mannose receptor (MR) and complement receptor 3 (CR3) have historically been considered the major macrophage lectins involved in the nonopsonic recognition of these yeast-derived particles. Using specific carbohydrate inhibito...

We describe outcomes after human leukocyte antigen-matched sibling bone marrow transplantation (BMT) for 179 patients with β-thalassemia major. The median age at transplantation was 7 years and the median follow-up was 6 years. The distribution of Pesaro risk class I, II, and III categories was 2%, 42%, and 36%, respectively. The day 30 cumulative incidence of neutrophil recovery and day 100 pl...

The presence of apparently normal hematopoietic tissue outside of bone marrow cavity is defined as extramedullary hematopoiesis (EMH). EMH is a rare complication in thalassemia major (TM) and adrenal gland as well. This report describes a case of adrenal EMH in a 26-year-old man with β-TM. He has been transfused with regular blood transfusion since 9 months. During the routine physical examinat...

Background: In recent years, the success in management of thalassemic patients, has allowed for some previously unrecognized complications including renal abnormalities to emerge. This prospective study aimed to investigate kidney iron overload by means of MRI T2* and also renal function based on laboratory tests for early markers of glomerular and tubular dysfunction among adult Iranian transf...

β-thalassemia is the most common single gene disorder worldwide, in which hemoglobin β-chain production is decreased. Today, the life expectancy of thalassemic patients is increased because of a variety of treatment methods; however treatment related complications have also increased. The most common side effect is osteoporosis, which usually occurs in early adulthood as a consequence of increa...