BACKGROUND Canine osteosarcoma (OS) is associated with localized pain as a result of tissue injury from tumor infiltration and peritumoral inflammation. Malignant bone pain is caused by stimulation of peripheral pain receptors, termed nociceptors, which reside in the localized tumor microenvironment, including the periosteal and intramedullary bone cavities. Several nociceptive ligands have bee...

Musculoskeletal system neoplasms must be accessed by a multidisciplinary clinical team, comprised by an orthopedic oncologist, a pathologist and a radiologist. Most of times, the central question to be answered before treatment is whether the tumor has malignant characteristics or not. After treatment, the question shifts to whether the tumor has been completely resected or destroyed and if the...

Abstract Objective The relationship between the adolescent and young adult age groups poor overall survival in soft tissue sarcoma risk factors for outcomes patients with were analyzed. Methods medical records of 7759 Japanese diagnosed from 2006–13 accessed Bone Soft Tissue Tumor registry. epidemiological features compared those other groups. cancer rates calculated using Kaplan-Meier method. ...

primary and secondary malignant central nervous system (cns) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. glioblastoma multiform (gbm), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced dna damage repair program that also induces recurrence and resists current chemo- and radio...

BACKGROUND Although primary bone tumors are relatively uncommon, they constitute the most important tumors in patients less than 20 years. We aimed to determine the frequencies of primary bone tumors and tumor-like lesions of bone and the anatomical sites of their occurrence. METHODS A retrospective review of histopathology reports of all bone specimens received in a private pathology laborat...

Sarcomas are malignant tumors of mesenchymal origin. They comprise < 1% adult malignancies and about 15-20% pediatric malignancies. These subdivided into bone cartilage sarcomas soft tissue type. the maxillofacial region 5-10% all this part body. Usually do not originate from benign tumors. Among factors known to induce sarcoma growth are: genetic defects, exposure pesticides herbicides, ionizi...

BACKGROUND Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. They are malignant in 20 % of cases. Only a few cases of malignant phyllodes tumors metastatic to bone have been reported. CASE PRESENTATION Case 1: A 40 year-old white woman presented with three-week history of pain and functional impairment of the left lower limb. Her clinical p...

SUMMARY Hemangioendotheliomas are rare vascular tumors that can affect bone. They account for 0.5% to 1.0% of malignant primary bone tumors. Only four cases have been reported involving the temporal bone. A 5-year-old child with grade II hemangioendothelioma of the right temporal bone is presented, and the radiologic findings on different imaging studies are described. The patient was treated w...

BACKGROUND: Below-knee amputation (BKA) is the safest treatment for benign aggressive and malignant bone tumours of distal tibia, yielding good oncological functional results. However, in selected patients where limb salvage feasible unacceptable to patient, using a tibial replacement (DTR) can be considered. This study aims present results use latter method our unit. METHODS: A retrospective f...