We reviewed the literature about entero-pancreatic neuroendocrine tumors in Multiple Endocrine Neoplasia type 1 syndrome (MEN1) to clarify their demographic features, localization imaging, practice, and appropriate therapeutical strategies, analyzing the current approach to entero-pancreatic neuroendocrine tumors in MEN1. Despite the fact that hyperparathyroidism is usually the first manifestat...

Malignant degeneration of wounds is rare and often misdiagnosed. Delay in diagnosis may result in a worse prognosis. The aim of this study is to determine the number of skin cancers associated with chronic skin ulcers in our facility over a period of 10 years. Between January 2002 and December 2012, a total of about 1000 patients had consulted with us for chronic wounds, especially of vascular,...

a 41 year old woman was referred to our center because of a left breast mass lesion of about two months duration. routine pathologic examination of the mass revealed a .neoplastic tissue composed of large ovoid cells with clear cytoplasm arranged in broad sheets that were separated by thin bundles of connective tissue. immunohistochemically tumor cells express smooth muscle actin, cytokeratin, ...

a 17 year old male who underwent surgery for thoracic outlet syndrome developed a postoperative complication which was labelled and diagnosed as malignant hyperthermia in kerman medical center. the temperature recorded was 43°c, pac02 70 mmhg and serum potassium level was 7 meq/l. the patient was hospitalized in the intensive care unit for 10 days. on discharge, the patient had aphasia and inco...

postmortem examination of a 5.5-year-old holstein cow with history of sudden death showed a veryhuge spleen (120 × 45 × 10 cm) associated with severe haemoperitoneum. histopathological findingsincluded extensive infiltration of medium to large sized lymphocytic and lymphoblastic cells with smallamounts of cytoplasm, round nuclei with coarsely granular chromatin in the spleen, and limited foci o...

osteosarcoma is a primary malignant tumor of bone, which can involve jaws. this article reviews osteosarcoma of the jaws referred to the department of oral pathology, dental faculty of tehran university of medical sicences and pathology department of cancer institiute in imam khomeini hospital during 30 years from 1349 to 1378 and also reviews jaw osteosarcoma in english literature. the purpose...

results using these two sets, we identified h1069q mutation in four patients, c.2335t > g mutation in three, c.3061-1g > a splice site mutation in five, c.3305t > c mutation in one, and c.3809a > g mutation in two patients. conclusions the multiplex arms assay used in this study can be an efficient, reliable, and cost effective method as a primary screen for patients with wilson disease. patien...

purpose : to assess the results of intracorneal ring (icr) segments for treatment of patients with pellucid marginal degeneration (pmd) methods : in this prospective interventional case series study, eight eyes of 5 patients with pmd who were contact lens intolerant received one or two intacs (intacs, addition technology) segments. preoperative and postoperative evaluations included slit-lamp e...

Malignant Catarrhal Fever (MCF) is a fatal lymphoproliferative disease of cattle and other ungulates caused by alcelaphine herpesvirus 1 (AlHV-1) ovine 2 (OvHV-2), the main causative agents wildebeest-associated MCF (WA-MCF) sheep-associated (SA-MCF), respectively. The virus mainly spread aerosols from pregnant or newborn sheep, goats, wildebeest to susceptible animals. This case report present...

1 Michael V. DeFazio, MD Jerry W. Chao, MD Albert K. Oh, MD Gary F. Rogers, MD Division of Plastic and Reconstructive Surgery Children’s National Medical Center Wash. Sir: G congenital blue nevi (GCBN) are rare dermal melanocytic proliferations that are distinguished by their large size, aggressive behavior, and propensity for malignant degeneration.1 To date, only 18 cases of GCBN involving th...