haematologica/the hematology journal | 2007; 92(12) | 1589 | Bor T-lymphocyte-mediated autoimmune disorders may lead to clinical disease characterized by low blood cell counts. The term autoimmune cytopenias has been collectively applied to this heterogeneous group of disorders. After the introduction of the humanized, chimeric monoclonal anti-CD20 antibody, rituximab, as a powerful therapeutic...

This study evaluated the toxicity profiles of temozolomide in the treatment of malignant glioma as either concurrent or adjuvant chemotherapy. We retrospectively reviewed the medical records of 300 malignant glioma patients treated with temozolomide in two medical institutions in Korea between 2004 and 2010. Two hundred nine patients experienced a total of 618 toxicities during temozolomide the...

Allogeneic hematopoietic stem cell transplantation (HSCT) has been widely used for the treatment of hematologic malignant and non-malignant hematologic diseases and other diseases. However, acute graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic transplantation. Acute GVHD may occur in 30% of transplant recipients, which is a syndrome of erythematous skin eruptio...

Percutaneous vertebroplasty (PVP) is a procedure in which bone cement is injected into vertebrae under fluoroscopic guidance. It was reported to be effective and safe for the treatment of back pain due to compression fractures of the spine [1,2]. As PVP has been successfully used to treat compression fractures of the spine in patients with malignant and non-malignant hematologic diseases, we th...

Autoimmune neutropenia (AIN), resulting from granulocyte-specific autoantibodies, is much less frequent than other autoimmune hematologic disorders including autoimmune hemolytic anemia (AIHA) and immune thrombocytopenia (ITP). These autoimmune disorders may precede, synchronize, or follow collagen disorders, viral infections, and lymphoid neoplasms. Herein we present the first case of AIN in a...

BACKGROUND Benzene is a widely distributed environmental contaminant known to cause leukemia, particularly acute nonlymphocytic leukemia, and perhaps other hematologic neoplasms and disorders. Few epidemiologic studies, however, have been able to address relationships between the extent of benzene exposure and the level of risk. PURPOSE A large cohort study was carried out in China to evaluat...

Objective. Drugs can induce almost the entire spectrum of hematologic disorders, affecting white cells, red cells, platelets, and the coagulation system. This paper aims to emphasize the broad range of drug-induced hematological syndromes and to highlight some of the newer drugs and syndromes. Methods. Medline literature on drug-induced hematologic syndromes was reviewed. Most reports and revie...

Monoclonal antibodies (MoAb) are valuable tools in better defining hematologic malignancies, both for diagnostic purposes and for understanding normal and malignant differentiation [1-5]. In the present study, we characterized the bone marrow cells of a young child with acute myelomonocytic leukemia (AMML). The unusual immunologic phenotype in this case not only allows more insight into myelomo...

Background: To better manage the COVID-19 pandemic, it is necessary to carefully study information about patients with COVID-19. Objective: report clinical and epidemiological characteristics of in southern Iran. Methods: This cross-sectional retrospective was conducted based on data extracted from registry Hormozgan. Data confirmed CT-scan results or real-time reverse transcriptase–polymerase ...

Background: Tracheostomy is a surgical procedure, often life saving measure in variety of clinical conditions. It one the commonest procedures carried out on critically ill patient. The most common causes non-malignant airway obstruction are head and severe facial trauma, cerebrovascular accident, coma, respiratory burn presence foreign bodies etc. an increasingly utilised adjunct ICU managemen...