Gorlin syndrome and rhabdoid tumor predisposition syndrome (RTPS) are autosomal dominant syndromes associated with an increased risk of childhood-onset brain tumors. Individuals with Gorlin syndrome can manifest a wide range of phenotypic abnormalities, with about 5% of family members developing medulloblastoma, usually occurring in the first 3 years of life. Gorlin syndrome is associated with ...

OBJECTIVE Atypical teratoid rhabdoid tumor is a rare neoplasm with a distinct cytogenetic profile that predominates in infancy. Many cases show predominance of small cells with scanty rhabdoid cells, making recognition of this tumor difficult. We aim at describing our experience with atypical teratoid rhabdoid tumor cases diagnosed over a 6-year period. MATERIAL AND METHOD Clinicopathologic f...

Rhabdoid tumors, which tend to occur prior to the age of 2 years, are one of the most aggressive malignancies and have a poor prognosis due to the frequency of metastasis. Silibinin, a natural extract, has been approved as a potential tumor suppressor in various studies, however, whether or not it also exerts its antitumor capacity in rhabdoid tumors, particularly with regards to tumor migratio...

ATYPICAL TERATOID RHABDOID TUMOR

The expression of GOK, a gene recently identified at llplS.5, was studied in breast cancer, rhabdomyosarcoma, and rhabdoid tumor cell lines. In these neoplasms, deletions at llplS and suppression of tumorigenicity induced by a normal human chromosome II were previously demonstrated. Whereas breast cancer cell lines express readily detectable levels of GOK mRNA, expression is absent in rhabdomyo...

malignant fibrous histiocytoma (mfh) is the most common soft-tissue sarcoma which predominantly surfaces in the retro-peritoneum and extremity. mfh of lung is a very rare condition. the diagnosis is essentially through histologic examination. however, the invasion of the chest wall or other organs might help establish the malignant nature.we report a case of a 77-year-old man who had been prese...

conclusions in patients with abdominal or pelvic masses and a history of previous abdominal surgery, the possibility of gossypiboma should be kept in mind. case presentation we report two patients (the first patient was 50 years old, with a history of an appendectomy three years ago in another city; the second patient was 52 years old, with a history of a cesarean section 25 years ago in anothe...