Our aim is to propose a new approach to breast pattern classification that will aid in the development of an automated mammographic density analysis procedure. Breast patterns broadly classify the mammographic density and density distribution of each mammogram in order to provide a framework for assessing the risk of breast cancer according to density. However, basic weaknesses of classifying m...

Introduction Mammographic breast density is positively associated with risk of developing breast cancer for both preand postmenopausal women. Breast Imaging Reporting and Data System (BIRADS) or similar semiquantitative pattern analyses are inexpensive and suitable for large epidemiologic studies, but intrareader reliability in interpretation is suboptimal. Continuous, computerassisted measurem...

Previously, we described the reduction in mammographic densities that occurred in premenopausal women after 12 months on a hormonal regimen designed to be chemopreventive for breast (and ovarian) cancer consisting of a gonadotropin-releasing hormone agonist (GnRHA) plus low-dose add-back estrogen-progestin. We sought to determine whether the density reduction persisted with continuation of the ...

Previous studies have linked reductions in mammographic density after a breast cancer diagnosis to an improved prognosis. These studies focused on short-term change, using a 2-stage process, treating estimated change as a fixed covariate in a survival model. We propose the use of a joint longitudinal-survival model. This enables us to model long-term trends in density while accounting for dropo...

BACKGROUND It is helpful in planning treatment for patients with ductal carcinoma in situ (DCIS) if the size and grade could be reliably predicted from the mammography. The aims of this study were to determine if the type of calcification can be best used to predict histopathological grade from the mammograms, to examine the association of mammographic appearance of DCIS with grade and to asses...

Mammographic density is one of the strongest predictors of breast cancer risk. Typically expressed as a percentage of the breast area occupied by radiologically dense tissue on a mammogram, its full value may not be realized because of its negative association with body mass index. A simpler measure of mammographic density, independent of other breast cancer risk factors and equally predictive ...

BACKGROUND High mammographic density might mask breast tumors, resulting in delayed diagnosis or missed cancers. PURPOSE To investigate the association between mammographic density and histopathologic tumor characteristics (histologic type, size, grade, and lymph node status) among women screened in the Norwegian Breast Cancer Screening Program. MATERIAL AND METHODS Information about 1760 s...

Soy supplementation by patients with breast cancer remains controversial. No controlled intervention studies have investigated the effects of soy supplementation on mammographic density in patients with breast cancer. We conducted a double-blind, randomized, placebo-controlled intervention study in previously treated patients with breast cancer (n = 66) and high-risk women (n = 29). We obtained...