1. The possible natriuretic and kaliuretic effects of a single dose of lithium, as used in lithium clearance studies, were investigated in 15 healthy subjects on fixed sodium (100 mmol/24 h) and potassium (70 mmol/24 h) intakes. Lithium carbonate (300 mg or 600 mg) or placebo tablets were administered, double-blind and in random order, midway through a 48 h urine collection (divided into six 8 ...

This short paper is intended to highlight some of the research contributions of Tony Guttmann on the occasion of his sixtieth birthday.

Sepoy Man Bahadur, No. 726/8, of the Myitkyina Military Police Battalion, has been under in}' observation for nca.ly 18 months, and from the very beginning tubercle of the lung has been suspected. In the early part of 1908 when he first came under observation he had no physical signs of phthisis; lie was, however, losing flesh, had a slight cough and is said to have spat some blood. His sputum ...

After ingestion of a non-absorbable carbohydrate breath hydrogen excretion increases early at about 10 minutes, and again later when the ingested carbohydrate enters the caecum. The late rise has been used as a marker of mouth to caecum transit time, but the source of the early rise has not been satisfactorily explained. We studied in 60 healthy volunteers the source and frequency of the early ...

The quantity of deuterated glucose customarily given in labelled IVGTTs (intravenous glucose tolerance tests) changes the isotopic composition of the subject's body water enough to be detected by mass spectrometric techniques. Glucose undergoing direct glycogenesis does not contribute label to the body water pool, and isotope incorporated into it must have come from glucose that has either been...