As binary switches, RAS proteins switch to an ON/OFF state during signaling and are on a leash under normal conditions. However, in RAS-related diseases such as cancer RASopathies, mutations the genes that regulate or itself permanently activate protein. The structural basis of this is well understood; however, exact mechanisms by which regulated less clear. RAS/MAPK syndromes multisystem devel...

Introduction and purpose: Sarcoidosis is a chronic, multi-system inflammatory disorder of unknown etiology. Due to the varied clinical picture patients, diagnosis disease complicated, especially when heart affected.The aim this article review available diagnostic tools used for diagnosis, evaluation monitoring patients with suspected cardiac sarcoidosis.
 Description state knowledge: may a...

COVID-19 is an ongoing multisystemic viral infection, which affects both adults and children. The virus has a complicated not fully understood pathophysiological mechanism of damaging different organs systems, including the skin. Cutaneous manifestations classification by great variety lesions histological appearances, neither specific. Herein, thorough overview clinical pathological peculiarit...