نتایج جستجو برای: map3k1
تعداد نتایج: 174 فیلتر نتایج به سال:
The Arabidopsis mitogen-activated protein kinase (MAPK) kinase 2 (MKK2) and the downstream MAPKs MPK4 and MPK6 were isolated by functional complementation of osmosensitive yeast mutants. In Arabidopsis protoplasts, MKK2 was specifically activated by cold and salt stress and by the stress-induced MAPK kinase kinase MEKK1. Yeast two-hybrid, in vitro, and in vivo protein kinase assays revealed tha...
INTRODUCTION Breast cancer (BC) is an important public health problem worldwide. In Brazil, breast cancer is the most frequently diagnosed tumor and the leading cause of cancer death in women. Hereditary cancer represents approximately 5 to 10 % of BC cases. Even outside the hereditary cancer context, the presence of polymorphisms acting as genetic modifiers may contribute to a better or worse ...
Chronic internal inflammation secondary to adiposity is a risk factor for sporadic breast cancer and Post-Menopausal Breast Cancer (PMBC) is largely defined as such. Adiposity is one of the clinical criteria for the diagnosis of Metabolic Syndrome (MetS) and is a risk factor for PMBC. We examined SNPs of eight genes implicated in adiposity, inflammation and cell proliferation in a Prospective-s...
BACKGROUND Major advances have been achieved in the characterization of early breast cancer (eBC) genomic profiles. Metastatic breast cancer (mBC) is associated with poor outcomes, yet limited information is available on the genomic profile of this disease. This study aims to decipher mutational profiles of mBC using next-generation sequencing. METHODS AND FINDINGS Whole-exome sequencing was ...
BACKGROUND Wheezing during early life is a very common disorder, but the reasons underlying the different wheezing phenotypes are still unclear. The aims of this study were to analyse the potential correlations between the risk of developing recurrent wheezing and the presence of specific polymorphisms of some genes regulating immune system function, and to study the relative importance of the ...
One of the most fundamental influences on our lives is our sex. Whether we are born as male or female has an enormous impact on our behaviour, reproductive options and disease susceptibility. Consequently, if the sex of a baby is not clear it can create many intractable issues, particularly in terms of medical management. Disorders of Sex Development (DSDs) are congenital conditions in which de...
Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. To identify novel common poly...
BACKGROUND Recently, several genome-wide association studies have identified various genetic susceptibility loci for breast cancer. Relatively little is known about the possible interactions between these loci and the established risk factors for breast cancer. METHODS To assess interactions between single-nucleotide polymorphisms (SNPs) and established risk factors, we prospectively collecte...
MEKK1 (MEK kinase 1) is a mammalian serineythreonine kinase in the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK) group (1). Being the first mammalian homolog of STE11, a MAPKKK that activates the pheromone responsive MAPK cascade of budding yeast, MEKK1 as its name indicates was thought to be an activator of the MAPK kinase (MAPKK) MEK1y2 and thus an activator of the ERK MAPK c...
T lymphocytes undergo apoptosis in response to a variety of stimuli, including exposure to UV radiation and gamma-irradiation. While the mechanism by which stress stimuli induce apoptosis is not well understood, we have previously shown that the induction of Fas ligand (FasL) gene expression by environmental stress stimuli is dependent on c-Jun N-terminal kinase (JNK) activation. Using inducibl...
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