Background T1 Mapping has emerged as a new marker to quantify myocardial extracellular volume (ECV), which is typically increased in the setting of diffuse fibrosis or infiltrative heart diseases. However the reproducibility of the technique is largely unknown. We sought to identify the interobserver, intraobserver variability of different T1 mapping techniques as well as validation of one tech...

Although the most important prognostic and predictive marker in colorectal cancer is tumor cells in lymph nodes, approximately 30% of patients who are node-negative die from occult metastases. Molecular staging employing specific markers and sensitive detection technologies has emerged as a powerful platform to assess prognosis in node-negative colon cancer. Integrating molecular staging into a...

The identification of informative in silico polymorphic genomic and genic microsatellite markers by comparing the genome and transcriptome sequences of crop genotypes is a rapid, cost-effective and non-laborious approach for large-scale marker validation and genotyping applications, including construction of high-density genetic maps. We designed 1494 markers, including 1016 genomic and 478 tra...

Abstract Purpose Increasing access to marker-less technology has enabled practitioners obtain kinematic data more quickly. However, the validation of many these methods is lacking. Therefore, validity pre-trained neural networks was explored in this study compared reflective marker tracking from sagittal plane cycling motion. Methods Twenty-six cyclists were assessed during stationary at self-s...

BACKGROUND Marker sets developed for gait analysis are often applied to more dynamic tasks with little or no validation, despite known complications of soft tissue artifact. METHODS This study presents a comparison of hip and knee kinematics as calculated by five concurrently-worn tracking marker sets during eight different tasks. The first three marker sets were based on Helen Hayes but used...

Background Pediatric cancer survivors after anthracycline therapy are at risk for left ventricular systolic dysfunction. Strain may be a more sensitive marker than left ventricular ejection fraction (LVEF). Feature tracking (FT) is a promising technique for strain measurement on cardiovascular magnetic resonance (CMR) images, but has limited validation vs. the gold standard of harmonic phase (H...

In their study of FRA in lung adenocarcinoma, O'Shannessy et al employed rigorous validation of a potentially useful clinical tool--using an immunohistochemical assay with a specific monoclonal antibody, they show that FRA expression is relatively specific for lung adenocarcinoma and that high FRA expression is associated with improved survival. Though further work will be necessary to translat...

septicemia in neonates is the commonest cause of mortality. early recognition and diagnosis of neonatal sepsis remains a challenge because of the variable and nonspecific clinical presentation. the laboratory criteria are often non specific and not fully reliable. the objective of this review is to highlight the various hematological and biological markers of neonatal sepsis. we searched pubmed...

Empirical estimates of the accuracy breeding values (EBV) can be obtained by cross-validation. Leave-one-out cross-validation (LOOCV) is an extreme case k-fold Efficient strategies for LOOCV predictions phenotypes have been developed a simple model with overall mean and random marker or animal genetic effects. The objective here was to develop evaluate efficient method prediction other effects ...