HYPOTHESIS Toremifen is effective in reducing breast pain and does not increase the incidence of adverse events as a therapy for moderate to severe mastalgia. DESIGN AND PATIENTS In a double-blind randomized controlled trial, patients with moderate to severe mastalgia received toremifen citrate, 30 mg daily, or a placebo tablet for 3 menstrual cycles and were followed up for breast pain score...

phase increases in plasma fibrinogen concentration and viscosity. In particular, however, we found that the filterability of both polymorphonuclear and mononuclear leucocytes is reduced in acute cerebral infarction. This may not only explain the reduced filterability of blood but also promote malperfusion of the microcirculation and infarction. Reduced filterability of leucocytes may be part of...

Many physicians, midwives and lactation consultants still believe that yeasts (particularly Candida spp.) play an important role as an agent of nipple and breast pain despite the absolute absence of scientific proofs to establish such association. In this context, the objective of this study was to investigate the microorganisms involved in sore nipples and/or painful "shooting" breastfeeding b...

Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign mesenchymal proliferative lesion of the breast. In this study, we aimed to show a case of PASH with mammographic and sonographic features, which fulfill the criteria for benign lesions and to define its recently discovered elastography findings. A 49-year-old premenopausal female presented with breast pain in our outpatient surgery c...

This review compares the tolerability profiles of the three currently available nonsteroidal antiandrogens, flutamide, bicalutamide and nilutamide. Pharmacological effects associated with blockade of the androgen receptor are frequent with all three drugs. Gynecomastia and breast pain are seen more frequently during antiandrogen monotherapy than during combination with medical or surgical castr...

Background: Breast cancer confronts women with a threat to life and is classified among the most traumatic life experiences. The disease is often accompanied by strong negative emotions, often in the form of anxiety and depressive symptoms. Studies also point to the presence of chronic pain breast-cancer survivors. Objective: To determine the relationships of: (1) anxiety and depressive symptom...

Bipolar disorder and severe premenstrual syndrome (PMS) have many symptoms in common, but it is important to establish the correct diagnosis between a severe psychiatric disorder and an endocrine disorder appropriately treatable with hormones. The measurement of hormone levels is not helpful in making this distinction, as they are all premenopausal women with normal follicle-stimulating hormone...

OBJECTIVE Vitex agnus-castus (VAC) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. In this study, the effects of essential oil extracted from Vitex agnus-castus (EOVAC) leaves were investigated in three behavioral models of nociception in adult male Wistar rats. MATER...

A 45-year-old nonlactating female presented to the emergency department (ED) fast-track area with a chief complaint of breast pain associated with redness. The symptoms occurred over a period of weeks. There were no constitutional symptoms of fever, chills, or weight loss. The patient had no known personal or family history of breast cancer. On physical examination, there was a 6by 3-cm conflue...

Introduction: Medical undergraduates are heavily burdened by their curriculum. The females, in addition, suffer from vivid affective or somatic premenstrual syndrome (PMS) symptoms such as bloating, mastalgia, insomnia, fatigue, mood swings, irritability, and depression. The present study was proposed to attenuate the symptoms of PMS by simple lifestyle measures like yoga and/or oral calcium. M...