OBJECTIVE The aim of this study in pregnant women with hypothyroidism treated by levothyroxine is to examine the interrelations between thyroid-stimulating hormone (TSH), free thyroxine (FT(4)) and free tri-iodothyronine (FT(3)), and examine whether in such patients the treatment is adequate. METHODS This was a retrospective cross-sectional study. Maternal serum concentrations of FT(3), FT(4)...

Postpartum thyroiditis is one of the autoimmune thyroid dysfunctions which occurs during 12 months after delivery. Transient episodes of hypo­and hyperthyroidism in this disorder leads to maternal psychological and physical problems. Irreversible hypothyroidism occurs in a number of mothers. The prevalence and clinical course of the disease haven't been evaluated before, so this study was condu...

BACKGROUND Thyroid gland disorders are variably associated with Prader-Willi syndrome (PWS). Many of the clinical features in newborns with PWS are similar to those found in congenital hypothyroidism (CH). CASE PRESENTATION We report a case of a girl with CH and PWS. At the age of 9 months CH caused by an ectopic sublingual thyroid was diagnosed, and hormone replacement therapy was started. I...

Genetic defects resulting in deficiency of thyroid hormone synthesis can be found in about 10% of the patients with permanent congenital hypothyroidism, but the identification of genetic abnormalities in association with the transient form of the disease is extremely rare. We report the case of a boy with transient neonatal hypothyroidism that was undiagnosed in the neonatal screening, associat...

Background Several conditions have been known to causetransient congenital hypothyroidism (TCH), including transplacental passage of TSH receptor blocking antibody (TSBAb), maternal antithyroid drug usage, iodine deficiency, iodine excess, fetal prematurity and inactivatingDUOX2mutations. However, the underlying etiology of TCH is not determined in some cases. In this study, we conducted the fi...

Aim: To detect the thyroidal dysfunction during pregnancy and related outcomes. Study Design: Prospective study. Place duration of study: Department Obstetrics & Gynaecology, S. Z. Hospital Lahore from 01-01-2021 to 30-06-2022 Methodology: One thousand pregnant women in third trimester were enrolled for thyroid function test screening, analysis TSH, free T3 T4 level. Results: Only 30 (3%) w...

Background: Thyroid dysfunction is one of the most common endocrine disorders affecting women reproductive age group. There a debate among obstetricians about universal versus targeted screening for hypothyroidism during pregnancy. Therefore, we conducted this study with aim to highlight need pregnant hypothyroidism. Methods: This was prospective analytical involving 200 in tertiary care hospit...

OBJECTIVE To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. DESIGN Prospective cohort study. SETTING Avon Longitudinal Study of Parents and Children cohort in the UK. PARTICIPANTS 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile...

Although evidence suggests that maternal hypothyroidism and mild hypothyroxinemia during the first half of pregnancy alters fetal neurodevelopment among euthyroid offspring, little data are available from later in gestation. In this study, we measured free T4 using direct equilibrium dialysis, as well as total T4 and TSH in 287 pregnant women at 27 weeks' gestation. We also assessed cognition, ...

Because thyroid disease is the second most common endocrine disease affecting women of reproductive age, obstetricians often care for patients who have been previously diagnosed with alterations in thyroid gland function. In addition, both hyperthyroidism and hypothyroidism may initially manifest during pregnancy. Obstetric conditions, such as gestational trophoblastic disease or hyperemesis gr...