Background An individual's overall burden of behavioural and emotional problems across childhood is associated with increased likelihood later mental health conditions. However, the relative extent versus - that is, to which domains are differentiated from one another may provide additional information about who at risk developing a condition. Here, we seek validate differentiation as an indepe...

Maternal depression has been found to be a risk factor in the development of child psychopathology (Burke, 2003) and more specifically, in the development of child externalizing disorders (Brennan et al., 2000; Hay et al., 2003; Kim-Cohen et al., 2005). The relation between maternal depression and poor parenting has also been identified in a number of contexts (Lovejoy et al., 2000; Shay & Knut...

WHAT IS ALREADY KNOWN ON THIS TOPIC? Advanced maternal age has long been acknowledged as a risk factor for genetic disorders such as Down’s syndrome. Owing to the large number of cell divisions that occur during spermatogenesis, we can speculate that advanced paternal age (APA) can contribute to an increased number of de novo mutations. Autosomal dominant diseases such as achondroplasia and mul...

Much of the knowledge about relationships among domains psychopathology is built on diagnostic categories described in Diagnostic and Statistical Manual Mental Disorders ( DSM), relatively little research has examined symptom-level structure psychopathology. The aim this study was to delineate a detailed hierarchical model psychopathology—from individual symptoms up general factor psychopatholo...

Association of tobacco and lead exposures with attention-deficit/hyperactivity disorder. Pediatrics 2009;124: e1054–63. 22 Biederman J, Monuteaux MC, Faraone SV, Mick E. Parsing the associations between prenatal exposure to nicotine and offspring psychopathology in a nonreferred sample. J Adolesc Health 2009;45:142–48. 23 Thapar A, Rice F, Hay D, Boivin J et al. Response to: testing the associa...