Homeobox genes Gsx1 and Gsx2 (formerly Gsh1 and Gsh2) are among the earliest transcription factors expressed in neuronal progenitors of the lateral ganglionic eminence (LGE) in the ventral telencephalon. Gsx2 is required for the early specification of LGE progenitor cells and recently has been shown to specify different LGE neuronal subtypes at distinct time points. In Gsx2 mutants, Gsx1 compen...

Differentiation from asexual blood stages to mature sexual gametocytes is required for the transmission of malaria parasites. Here, we report that ApiAP2 transcription factor, PfAP2-G2 (PF3D7_1408200) plays a critical role in maturation Plasmodium falciparum gametocytes. binds promoters wide array genes are expressed at many parasite life cycle. Interestingly, also find binding within gene body...

In sexually reproducing animals, the ability to coordinate oocyte maturation and sperm availability has profound effects on reproductive success. InCaenorhabditis elegans, cell–cell signaling is crucial for promoting germline development, oocyte maturation, and ovulation. In this issue of Genes & Development, Miller et al. (2003) provide new insights into the role that sperm play in oocyte matu...

BACKGROUND Accumulating evidences suggest that sex affects lung development. Indeed, a higher incidence of respiratory distress syndrome is observed in male compared to female preterm neonates at comparable developmental stage and experimental studies demonstrated an androgen-related delay in male lung maturation. However, the precise mechanisms underlying these deleterious effects of androgens...

Diplonemid mitochondria are considered to have very eccentric structural genes. Coding regions of individual diplonemid mitochondrial genes are fragmented into small pieces and found on different circular DNAs. Short RNAs transcribed from each DNA molecule mature through a unique RNA maturation process involving assembly and three types of RNA editing (i.e., U insertion and A-to-I & C-to-U subs...

The elaboration of a quality oocyte is integrally linked to the correct developmental progression of cumulus cell phenotype. In humans and nonhuman primates, oocyte quality is diminished with in vitro maturation. To determine the changes in gene expression in rhesus monkey cumulus cells (CC) that occur during the final day prior to oocyte maturation and how these changes differ between in vitro...

Soybean [Glycine max (L.) Merr.] is produced in 93 countries of the world on 120.5 million hectares. The production area crop located between 56N. (Russian Federation) and 35-37S (Argentina). In gene pool crop, there a wide variety genotypes different maturity groups, which every has relatively narrow latitudinal adaptability, depends heat moisture supply duration photoperiod. An urgent problem...

The pituitary gland is a neuroendocrine organ that works closely with the hypothalamus to affect multiple processes within the body including the stress response, metabolism, growth and immune function. Relative tissue expression (rEx) is a transcriptome analysis method that compares the genes expressed in a particular tissue to the genes expressed in all other tissues with available data. Usin...

Integration of prokaryotic nitrogen fixation ( nif ) genes into the plastid genome for expression functional nitrogenase components could render plants capable assimilating atmospheric N 2 making their crops less dependent fertilizers. The Fe protein component (NifH) has been used as proxy and targeting Nif proteins within plant yeast cells. Here we use tobacco with Azotobacter vinelandii nifH ...

In the nitrogenase system of Klebsiella pneumoniae, nifT is located between nifDK, the structural genes for dinitrogenase, and nifY, whose product is involved in nitrogenase maturation. It is, therefore, a reasonable hypothesis that the NifT protein might also have a role in the maturation of nitrogenase. However, the phenotypic characterization of nifT and nifT-overexpressing strains for effec...