Objectives We studied the relations between synovial vascularity (SV) and structural alteration of finger joints in patients with rheumatoid arthritis (RA) and long-term sustained clinical low disease activity (CLDA). Methods RA patients with CLDA of more than 2 years (minimum 1 year of CLDA for study entry plus 1 year of observation) were analysed. Quantitative SV values were sequentially meas...

BACKGROUND Studies in humans have shown that haemostatic and inflammatory pathways both play important roles in the pathogenesis of joint disease. The aim of this study was to assess mRNA expression of haemostatic and inflammatory factors in cultured equine fibroblast-like synoviocytes exposed to lipopolysaccharide (LPS), fibrinogen and thrombin. Synovial membranes were collected from metacarpo...

BACKGROUND There are few studies on radiographic outcome after long-term disease duration in juvenile idiopathic arthritis (JIA). We wanted to evaluate 29-year radiographic outcome in hands/wrists and predictors of damage in patients with long-term active JIA. METHODS Patients diagnosed from 1980 to 1985, who had active disease at 15-, 23- or 29-year follow-up and arthritis in the wrists duri...

Objectives. To assess the accuracy of blind IA injections (IAIs) in patients with RA and determine their effectiveness. Methods. A controlled prospective study including 96 RA patients undergoing blind IAIs in peripheral joints was carried out. Clinical evaluation was performed at baseline (T0), 1 (T1) and 4 (T4) weeks after IAI using the following instruments: visual analogue scale (VAS) for p...

Fifty eight patients suffering from a recent onset of rheumatoid arthritis (RA) were studied. Fifty six patients were followed up for 24 months and two for 18 months. Erosions were detected in 17 patients at the onset and at the end of the follow up period the number of patients with erosions was 44. The erosiveness in the joint groups studied was as follows: metatarsophalangeal (MTP) (36 patie...

A 72-year-old male with high-demand activities of daily living presented with rheumatoid arthritis mostly affected finger joints of his right hand. Radiographically, there was severe destruction with luxation of metacarpophalangeal joints (MCPJs) II-V. The constrained RM prostheses were inserted into the MCPJs II-V typically in the uncemented manner, and the course was primarily complicated due...

Rheumatoid arthritis (RA) patients with early elevations of antibodies against collagen type II (CII) have a distinct acute onset phenotype, associated with cytokine induction by surface-bound anti-CII-containing immune complexes (ICs) and high C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Polymorphonuclear granulocytes (PMNs) and peripheral blood mononuclear cells (PBMCs) ...

Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting approximately 1% of the world’s population (Lee and Weinblatt, 2001). Although inflammatory lesions in the skin, lungs, and other organs are common, the disease hallmark is severe, often destructive, inflammation of peripheral joints. Although manifestations vary among patients, RA is usually a symmetric polyarthritis affecti...

Carnation (Dianthus caryophyllus L.) is one of the most important cut flowers in the world. Themajority of thecarnation cultivars are sensitive to ethylene which affected the physiological and biochemical postharvest characteristics of these flowers.Applying inhibitors of biosynthesis and action of ethylene is important factor to protect the display quality and extend postharvest life. In order...