This study aimed to investigate and compare the incidence of metered-dose inhaler (MDI)-associated bronchoconstriction in an asthmatic population, following the use of three different MDIs. Two different placebo metered-dose inhaler preparations containing the same chlorofluorocarbons but differing in dispersant chemicals, one containing oleic acid (MDI-OA) and the other lecithin NF (MDI-L), we...

PURPOSE To study the influence of inspiratory flow rate on the fine particle mass and the particle size distribution for metered dose inhaler (MDI) and dry powder inhaler (DPI) glucocorticoid products, in vitro. To compare the performance of MDI and DPI inhalers containing the same drug and strength at an impaction flow rate of 60 L/min. METHODS The Marple Miller cascade impactor model 150 an...

BACKGROUND Metered dose inhalers (MDIs) are an affective modality of treatment for fast relief from asthma flare-ups and other symptoms, and are often used by asthmatic athletes. It has got lots of benefits and some drawbacks depending on usage technique. With proper technique and training drawbacks can be minimised. The objective of this study was to assess the metered dose inhaler technique i...

Elimination of sediments from river reservoirs is a common management problem for hydroelectric power plants. Periodical flushing can have negative impacts downstream. This study investigated the impact of a flushing event on the physico-chemical changes in the downstream sections and on the consequences for the benthic macroinvertebrate community. A special emphasis was placed on trace metal f...

BACKGROUND Handling of inhaler devices such as pressurized metered-dose inhalers (MDIs) and dry-powder inhalers (DPIs) in actual pulmonary practice is not well studied. OBJECTIVE The aim of this study was to evaluate patients' proper handling of inhaler devices during actual pulmonary practice. METHODS Prospective observational evaluations were conducted at 3 pulmonary clinics in Jordan, fr...

BACKGROUND A simple non-invasive method, in which a urine sample is taken 30 minutes after drug administration, has previously been shown to be a measure of the relative bioavailability of salbutamol to the lungs. This technique has been used to determine an optimal inhaler technique with commercially available metered dose inhalers (MDI). METHODS Ten healthy subjects were trained in the use ...

Cellular Digital Packet Data (CDPD) provides a sleep mode operation for power conservation in mobile end systems (M-ESs). We perform a theoretical analysis of sleep mode operation for CDPD. Sleep mode operation is modeled as an queueing system with an attention span and multiple vacations with an exceptional first vacation. The steady state probabilities of the queueing system, the frame loss p...

OBJECTIVE This primary objective of this pilot randomized, controlled trial was to determine whether a brief video intervention delivered after a pediatric office visit could improve inhaler technique in children with asthma immediately and one month later. The intervention's effect on children's inhaler self-efficacy and asthma control was also evaluated. METHODS Children (n=91) ages 7-17 ye...

Asthnia treat i t’nt CII1I)hasizeS inhaled medication’ to manage airway inflalllluatiou.2 Because ofdifflculties encountered in the USC of metere(l-(lose inhalers (MDIs),3 ‘ mansphysicians recommend spacers.5’ A .56-year-old man with steroid-dependent asthma, vasculitis, and bilateral vision loss secondary to retinal artery ()cclusn)n used oral theophylline. oral pre(lniS 11e, and inhaled metap...

The introduction of pressurised metered dose inhalers (MDIs) in the mid-1950s completely transformed respiratory treatment. Despite decades of availability and healthcare support and development of teaching aids and devices to promote better use, poor pMDI user technique remains a persistent issue. The main pMDI user aid is the spacer/valved holding chamber (VHC) device. Spacer/chamber features...