نتایج جستجو برای: mdma

تعداد نتایج: 1792  

Journal: :FEBS letters 2004
Rabi Simantov Weiping Peng

In several countries, 3,4-methylenedioxymethamphetamine (MDMA) is currently the most abundant psychoactive recreational drug. MDMA induces numerous neuropsychiatric behaviors, serotonergic neuron degeneration, programmed death of cultured cells, hyperthermia and occasional fatality. Using gene expression analysis in MDMA-treated mice, we identified changes in gamma-amino butyric acid (GABA) tra...

2011
João Martins Miguel Castelo-Branco Ana Batista Bárbara Oliveiros Ana Raquel Santiago Joana Galvão Eduarda Fernandes Félix Carvalho Cláudia Cavadas António F. Ambrósio

3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is known to produce euphoric states, but may also cause adverse consequences in humans, such as hyperthermia and neurocognitive deficits. Although MDMA consumption has been associated with visual problems, the effects of this recreational drug in retinal physiology have not been addressed hitherto. In this work, we evaluated the effect of a sing...

Journal: :European journal of pharmacology 2011
Natacha Vanattou-Saïfoudine Anna Gossen Andrew Harkin

Co-administration of caffeine profoundly enhances the acute toxicity of 3,4 methylenedioxymethamphetamine (MDMA) in rats. The aim of this study was to determine the ability of caffeine to impact upon MDMA-induced dopamine release in superfused brain tissue slices as a contributing factor to this drug interaction. MDMA (100 and 300μM) induced a dose-dependent increase in dopamine release in stri...

2001
John H. Krystal George A. Ricaurte Charles Opsahl

332 KRYSTAL ET AL. MDMA EFFECTS ON MOOD AND COGNITIVE FUNCTION 333 Charles Opsahl, Ph.D. appetite suppressant [11. MDMA has been reported useful as an adjunct to Psychiatry Service psychotherapy through facilitating interpersonal communication, enhancing inYale-New Haven Hospital sight, increasing self-esteem, and decreasing the abuse of other illicit substances Department of Psychiatry and Psy...

Journal: :European journal of pharmacology 1990
J L Fitzgerald J J Reid

The effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamine release were investigated in superfused slices of rat striatum and hippocampus. MDMA (10 microM) increased the resting release of radioactivity from slices incubated in [3H]dopamine, [3H]5-hydroxytryptamine or [3H]noradrenaline. These effects of MDMA (10 microM) were blocked by the neuronal uptake inhibitors, cocaine (10 micro...

Journal: :Biological psychiatry 2001
L Reneman C B Majoie B Schmand W van den Brink G J den Heeten

BACKGROUND 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") is known to damage brain serotonin neurons in animals and possibly humans. Because serotonergic damage may adversely affect memory, we compared verbal memory function between MDMA users and MDMA-naïve control subjects and evaluated the relationship between verbal memory function and neuronal dysfunction in the MDMA users. METHOD...

Journal: :British journal of pharmacology 2013
J Rouine O L Gobbo M Campbell V Gigliucci I Ogden K McHugh Smith P Duffy B Behan D Byrne M E Kelly C W Blau C M Kerskens A Harkin

BACKGROUND AND PURPOSE The purpose of this study was to assess cerebral perfusion changes following systemic administration of the recreational drug 3,4-methylendioxymethamphetamine (MDMA 'ecstasy') to rats. EXPERIMENTAL APPROACH Cerebral perfusion was quantified using bolus-tracking arterial spin labelling (btASL) MRI. Rats received MDMA (20 mg·kg(-1); i.p.) and were assessed 1, 3 or 24 h la...

Journal: :Chemical research in toxicology 2001
M Segura J Ortuño M Farré J A McLure M Pujadas N Pizarro A Llebaria J Joglar P N Roset J Segura R de La Torre

There is evidence that some heavy users of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) show signs of neurotoxicity (a cognitive dysfunction, a larger incidence of psychopathology). It has been postulated that the catechol intermediates of methylenedioxyamphetamines such as 3,4-dihydroxymethamphetamine (HHMA), a metabolite of MDMA, may play a role in their neurotoxicity by formation of thi...

2009
Stéphane Doly Jesus Bertran-Gonzalez Jacques Callebert Alexandra Bruneau Sophie Marie Banas Arnauld Belmer Katia Boutourlinsky Denis Hervé Jean-Marie Launay Luc Maroteaux

The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) reverses dopamine and serotonin transporters to produce efflux of dopamine and serotonin, respectively, in regions of the brain that have been implicated in reward. However, the role of serotonin/dopamine interactions in the behavioral effects of MDMA remains unclear. We previously showed that MDMA-induced locomotion, ...

2009
Kimberly Scearce-Levie Sandya S. Viswanathan René Hen

3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive drug of abuse which is increasingly popular in human recreational drug use. In rats, the drug has been shown to stimulate locomotion while decreasing exploratory behavior. MDMA acts as an indirect agonist of serotonin (5-HT) receptors by inducing 5-HT release by a 5-HT reuptake transporterdependent mechanism, although it is not known wh...

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