MarA and its homologue, RamA, have been implicated in multidrug resistance (MDR). RamA overexpression in Salmonella enterica serovar Typhimurium and Escherichia coli conferred MDR independently of marA. Inactivation of ramA did not affect the antibiotic susceptibilities of wild-type S. enterica serovar Typhimurium or 15 unrelated clinical MDR isolates. Thus, ramA overexpression is not a common ...

Results The highest prevalence Gram-negative and Gram-positive bacteria in both wards were similar as Pseudomonas aeruginosa (20.99 and 15.17%) and Staphylococcus aureus (13.12 and 12.16%), respectively. Although the prevalence of multiple drug resistant (MDR) strains of Acinetobacter baumannii showed no differrence (59.09 vs 60.53%) in both wards, the prevelence of MDR P. aeruginosa and methic...

Members of the resistance-nodulation-division (RND) family of efflux pumps, such as AcrAB-TolC of Escherichia coli, play major roles in multidrug resistance (MDR) in Gram-negative bacteria. A strategy for combating MDR is to develop efflux pump inhibitors (EPIs) for use in combination with an antibacterial agent. Here, we describe MBX2319, a novel pyranopyridine EPI with potent activity against...

Several strains of Salmonella have been identified as resistant to multiple antibiotics. What is not known is whether strains possessing multidrug resistance properties also have the ability to resist the killing effects of the antimicrobial interventions used in beef processing. The research project described herein was designed to determine whether antimicrobial interventions currently in pla...

In this study 6 CTX-M positive E. coli isolates collected during a clinical study examining the effect of antibiotic use in a human trial were analysed. The aim of the study was to analyse these isolates and assess the effect of full or partial loss of plasmid genes on bacterial fitness and pathogenicity. A DNA array was utilised to assess resistance and virulence gene carriage. Plasmids were c...

Although meat and fish are prized delicacy in Nigeria, they can also spread germs that multidrug resistant (MDR). Moreover, research on these MDR bacteria from Awkametropolies is scarce. Thus, the bacteriological characteristics antibiogram profiles of E coli isolated were studied this investigation. Twenty different samples sites gathered microbiologically examined. Standard microbiological pr...

TolC is the outer-membrane component of several multidrug resistance (MDR) efflux pumps and plays an important role in the survival and virulence of many gram-negative bacterial animal pathogens. We have identified and characterized the outer-membrane protein-encoding gene tolC in the bacterial plant pathogen Erwinia chrysanthemi EC16. The gene was found to encode a 51-kDa protein with 70% iden...

CONTEXT Urinary tract infection (UTI) is one of the most common nosocomial infections, caused by Escherichia coli. This study determined the presence of virulence factors in the organism and correlates it with the multi-drug resistance (MDR). AIMS The aim of the following study is to assess the virulence factors of uropathogenic E. coli and antibiotic susceptibility pattern. SETTINGS AND DE...

The increase in multidrug-resistant bacteria represents a true challenge the pharmaceutical and biomedical fields. For this reason, research on development of new potential antibacterial strategies is essential. Here, we describe green system for synthesis silver nanoparticles (AgNPs) bioconjugated with chitosan. We optimized Prunus cerasus leaf extract as source its conversion to chitosan–silv...

Multidrug-resistant Escherichia coli is an emerging clinical challenge in domestic species. Treatment options in many cases are limited. This study characterized MDR E. coli isolates from urinary tract infections in dogs, collected between 2002 and 2011. Isolates were evaluated in terms of β-lactamase production, phylogenetic group, ST type, replicon type and virulence marker profile. Compariso...