Background: Studies have demonstrated that sickle cell trait can be found in an asymptomatic healthy carrier with normal complete blood count (CBC) and red blood cell (RBC) indices. According to Iranian Ministry of Health bulletin instructions, prenuptial Thalassemia Screening Program (TSP) primarily depends on RBC indices which are measured through a routine CBC. Only when these levels are bel...

background: sickle-cell anemia is characterized by defective hemoglobin synthesis with production of sickle hemoglobin. sickle red blood cells become deformed and rigid with difficulty to pass through narrow capillaries and frequent clotting and thrombosis leading to repetitive vascular occlusions and progressive organ damage. we conducted this work to study some adrenal functions using acth st...

As a body fluid, blood supplies nutrients and oxygen to cells carries away metabolic waste products. A cross-sectional study was conducted between February April 2021 in Khartoum state examine the effect of renal failure on hemoglobin level, mean cell volume (MCV), red distribution width (RDW) Sudanese patients. One hundred thirty-five samples were collected from patients with failure, 100 them...

The blood cell profile of captive sedated chital deer revealed a sickle shaped Red Blood Cell (RBC) with the total count of 5.07 ± 0.73 x 10 per cu. mm, the Hemoglobin (Hb) concentration of 10.92 ± 1.56 gm/dl, Packed Cell Volume (PCV) of 34.00 ± 5.19, Mean Corpuscular Volume (MCV) of 65.4 ± 1.46, Mean Corpuscular Hemoglobin (MCH) of 21.65 ± 0.21 and a total White Blood Corpuscles (WBC) was 9.1 ...

background: lead is a toxic element which causes acute, subacute or chronic poisoning through environmental and occupational exposure. the aim of this study was to investigate clinical and laboratory abnormalities of chronic lead poisoning among workers of a car battery industry. methods: questionnaires and forms were designed and used to record demographic data, past medical histories and clin...

Fetal hemoglobin (HbF) decreases polymerization of sickle hemoglobin (HbS) and improves outcomes in sickle cell disease (SSD). Therefore, a therapeutic goal in SSD is pharmacologic reactivation of HbF. Silencing of the gamma-globin (HbF) gene is associated with DNA methylation. The cytosine analog 5-aza-2'-deoxycytidine (decitabine) hypomethylates DNA by inhibiting DNA methyltransferase. We exa...

We examined hematological parameters in four related sciurid species in the late summer-autumn to assess the role of habitat, elevation, body size, and behavior in shaping these parameters. Red squirrels (Tamiasciurus hudsonicus) and Arctic ground squirrels (Spermophilus parryii) were sampled in southwestern Yukon, yellow-pine chipmunks (Tamias amoenus) in southern Alberta, and the eastern grey...

Recent studies suggest that leukocytes and erythrocytes play a role in coagulation. However, whether leukocytes, erythrocytes and other hematologic variables are associated with risk of venous thrombosis is not well known. To study this, we used data from 2473 patients with venous thrombosis and 2935 controls. The variables assessed were: total leukocytes, granulocytes, lymphocytes, monocytes, ...

Introduction: Exposure to ionizing radiation can trigger adverse biological effects on healthy tissues, such as causing hematological toxicity and potential injury to different organs. Ionizing radiation has sufficient energy to liberate electrons from atoms leaving them with unpaired electrons; hence ionizing them and producing free radicals. In the current study, the...

A very high glucose level in a diabetic was associated with an increased electronic mean corpuscular volume (MCV). The hematocrit was falsely high and the mean corpuscular hemoglobin concentration (MCHC) falsely low, while the mean corpuscular hemoglobin (MCH) was normal. Blood smears failed to corroborate the abdominal indices. Correct values could be obtained by predilution of the blood in is...