It is possible to recruit RNA polymerase II to a target promoter and, thus, activate transcription by fusing Mediator subunits to a DNA binding domain. To investigate functional interactions within Mediator, we have tested such fusions of the lexA DNA binding domain to Med1, Med2, Gal11, Srb7, and Srb10 in wild type, med1, med2, gal11, sin4, srb8, srb10, and srb11 strains. We found that lexA-Me...

A generic Mediator architecture for distributed task planning and coordination has been developed using multi-agent paradigms. In this approach, agents function autonomously as independent computing processes, and dynamic virtual clusters coordinate the agent’s activities and decision making. This coordination involves dynamically created coordination agents and resource agents concurrently. Th...

The previous studies about the maintenance systems were dealt with defining the evaluation criteria, grouping them, and using different techniques for evaluating. The main problem is that maintenance subsystems and the relationship between and within them in order to a reliable evaluation have never been identified before.The contribution of this study is realizing the four maintenance su...

The Mediator complex forms the bridge between transcriptional activators and RNA polymerase II. Mediator subunit Med1/TRAP220 is a key component of Mediator originally found to associate with nuclear hormone receptors. Med1 deficiency causes lethality at embryonic day 11.5 because of defects in heart and placenta development. Here we show that Med1-deficient 10.5 days postcoitum embryos are ane...

Eukaryotic chromosome ends have a DNA-protein complex structure termed telomere. Integrity of telomeres is essential for cell proliferation. Genome-wide screenings for telomere length maintenance genes identified several components of the transcriptional regulator, the Mediator complex. Our work provides evidence that Mediator is involved in telomere length regulation and telomere heterochromat...

Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans. We generated sur2-/- embryonic stem cells to analyze its function as a mammalian Mediator component. Our results show that Sur2 forms a subcomplex of the Mediator with two other subunits, TRAP/Med...

in the present study, through the application of self-determination theory the impact of work climate and social network size on the volunteers motivation were investigated. research type of this study is applied and research method type is descriptive. in this study active volunteers of tehran red crescent society were selected as statistical population .concerning the population of studied ce...

impulse buying behavior has a determinable role in developing the power of computability in the current consumer markets. hence, recognizing and improving the facilitating factors of impulse behavior is a necessity for increasing the profitability of such businesses. this research examines the effects of individual, environmental and fashion involvement factors by considering the mediator effec...