Resveratrol is a polyphenolic flavonoid initially identified as a phytoalexin and as a major constituent of red wine. However interest in this molecule initially developed as a cardioprotective agent and in due course of time therapeutic actions came into limelight. This article explores the different therapeutic activities of Resveratrol and highlights their possible mode of action responsible...

H A P T E R O U T L IN E 1. Learn about the basic chemistry related to atoms and molecules. Understand the roles of orbitals and lone-pair electrons in a few common atoms (e.g., N, F, C, O) and comprehend nucleophilic/electrophilic attacks and their impact on oxidation, reduction, addition, and substitution reactions. 2. List and explain the importance of medicinal functional groups that common...

* UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang,Selangor, Malaysia, ** Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia, *** Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University-Hadassah Medical School,Je...

The new journal Molecules publishes peer-reviewed research papers on synthetic chemistry and natural product chemistry. The rapid publication schedule requires that authors make sure their submitted or revised manuscripts are in the final form. In order to comply with this requirement, I considered treating the Corrigendum column as an advertisement and charging all authors who contribute to it...

Dendrimers are a new class of polymeric materials. They are highly branched, monodisperse macromolecules. Structural Advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The paper gives a brief review ...

The BioCreative V.5 challenge focused on the recognition of chemicals and gene mentions in medicinal chemistry patents. For participation in the chemical entity (CEMP) and gene and protein (GPRO) recognition tasks, we used the concept recognition framework Neji and applied a machine-learning strategy using a optimized feature set. Our best submissions achieved an F-score of 86.6% for the identi...

Within the realm of medicinal chemistry, synthesis plays a pivotal role in any drug research and development endeavor. The ability to design elegant and economical synthetic routes is often a major factor for making a drug a commercial winner. Retrosynthetic analysis/ Synthon disconnection approach, introduced and advanced by Prof. E. J. Corey of Harvard University has served as a powerful driv...

UNLABELLED High throughput screening of small molecules for a given drug target is achieved using plant materials of medicinal value. Therefore, it is important to document the availability and location of such medicinal plants in the form of a database. Here, we describe a web database containing information (botanical name, common name, local name, botany, chemistry, folklore medicinal use an...