Multiple Neuroendocrine Neoplasia (MEN) gained notoriety after its initial descriptions, but cases of MEN are extremely rare, especially type 2B, characterized by a clinical presentation involving Medullary Thyroid Carcinoma (MTC), pheochromocytoma, and mutagenic alterations with focus on the RET proto-oncogene. Surgical intervention stands out as primary curative treatment, in metastatic condi...

background the relationship between biomarkers and imaging features is important because imaging findings can predict molecular features. objectives to investigate the relationship between clinicopathologic and radiologic factors and the immunohistochemical (ihc) profiles associated with breast cancer. patients and methods from december 2004 to september 2013, 200 patients (mean age, 56 years; ...

Multiple endocrine neoplasia type 2 is an autosomal-dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the rearranged during transfection proto-oncogene, which encodes the receptor tyrosine kinase, on chromosome 10. It has a strong penetrance of medullary thyroid carcinomas and can be associated with bilateral pheochromocytoma and primary hyperparathyroidism. M...

Metastasis to the primary thyroid carcinoma is extremely rare. We report here a case of colonic adenocarcinoma metastasis to medullary thyroid carcinoma in a 53-yr old man with a history of colon cancer. He showed a nodular lesion, suggesting malignancy in the thyroid gland, in a follow-up examination after colon cancer surgery. Fine needle aspiration biopsy (FNAB) of the thyroid gland showed t...

Severe watery diarrhoea in a patient with medullary thryoid carcinoma and high calcitonin levels was associated with increased distal ileal flow. Plasma from the patient inhibited small intestinal fluid absorption in dogs without affecting mucosal cyclic AMP levels. When calcitonin was removed from the plasma, the effect in experimental bowel loops was abolished but could be restored on restitu...

We describe the complex presentation of a patient with renal medullary carcinoma, a newly described entity primarily affecting young patients with sickle cell trait. Renal medullary carcinoma is an aggressive, rapidly destructive tumor associated with a delayed diagnosis and a poor outcome. The most common presenting signs and symptoms include hematuria, abdominal or flank pain, and weight loss...