380 Ann Dermatol Received July 23, 2012, Revised September 26, 2012, Accepted for publication October 14, 2012 Corresponding author: Young Min Park, Department of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Korea. Tel: 82-2-2258-6223, Fax: 82-2-599-9950, E-mail: [email protected] This is an Open...

Congenital melanocytic nevus consists of congregations of nevomelanocytes. It is found in approximately 1% of new born infants. Congenital melanocytic nevus needs to be excised before it transforms into a malignant lesion. Many strategies have been attempted for the removal and reconstruction of the nevus. Serial excision enables wound closure to be accomplished with a shorter scar than if the ...

Halo (Sutton's) phenomenon has been described as a depigmented halo that is associated most commonly with acquired melanocytic nevi; but it may be associated with various types of melanocytic skin tumors, melanoma being the most concerning. Different authors have been preoccupied with elucidating morphological features of melanocytic tumors associated with a depigmented halo. We reviewed the li...

M elanocytic nevi, commonly referred to as moles, are very common in children, and the overwhelming majority of melanocytic nevi in children are benign. Given the increased general awareness of melanoma, however, caregivers often express concerns about the development or appearance of their child’s moles. An understanding of the more common types of melanocytic nevi seen in children and of the ...

A 2-year-old boy presents with a 4 x 3-cm, darkly pigmented nevus on his back. His mother states that this lesion has been present since birth. Both parents noticed that the nevus has become slightly larger but deny any other changes in its appearance. The boy is otherwise healthy. He has no allergies and does not take any medication. There is no family history of skin disease or cutaneous mali...

Intense pulsed light (IPL) therapy using noncoherent broad-spectrum light has been reported to be effective for hair removal, and also for treating superficial pigmented lesions like ephelides and solar lentigines. We report complete regression of a pigmented melanocytic nevus, histologically confirmed, after hair removal treatment with IPL. The use of lasers and IPL is a common procedure used ...

The production of pigment by melanocytic cells of the skin involves a series of enzymatic reactions that take place in specialized organelles called melanosomes. Melan-A/MART-1 is a melanocytic transmembrane protein with no enzymatic activity that accumulates in vesicles at the trans side of the Golgi and in melanosomes. We show here that, in melanoma cells, Melan-A associates with two homologo...

Melanoma is a lethal skin disease with a mostly predictable clinical course according to a known constellation of clinical and pathologic features. The distinction of melanoma from benign melanocytic nevus is typically unequivocol; however, there is a subset of tumors known for its diagnostic challenges, development of late metastases, and difficulties in treatment. Several melanocytic tissue b...