It has been hypothesized that cutaneous melanoma at different anatomic sites develops through divergent pathways. We examined this hypothesis prospectively. We followed 152,949 women and 25,204 men free of cancer at baseline for up to 14 years in three large prospective studies. We examined risk factors for melanoma by anatomic location (head or neck, trunk, upper extremity, and lower extremity...

The American Academy of Dermatology (AAD) has designated May as National Melanoma/Skin Cancer Detection and Prevention Month. In 1996, an estimated 1 million cases of skin cancer will be diagnosed, of which approximately 95% will be squamous cell or basal cell carcinomas (1). Although the incidence of melanoma is lower than those of squamous cell and basal cell carcinomas, the case-fatality rat...

The National Cancer Institute (NCI) defines skin cancer as a disease in which abnormal cells divide uncontrollably in the outer layers of the skin (1). The American Cancer Society's Facts and Figures 2001 (the latest year for which these figures are available) estimated that more than 1 million cases of highly curable basal cell or squamous cell cancers would be diagnosed in the United States t...

Melanoma is one of the deadliest skin tumors, accounting for almost 90% cancer mortality. Although immune therapy and targeted have dramatically changed prognosis metastatic melanoma, many patients experience disease progression despite currently available new treatments. Skin metastases from melanoma represent a relatively common event as first sign advanced or recurrence. are usually asymptom...

We have investigated the role of vascular-endothelial (VE)-cadherin in melanoma and breast cancer metastasis. We found that VE-cadherin is expressed in highly aggressive melanoma and breast cancer cell lines. Remarkably, inactivation of VE-cadherin triggered a significant loss of malignant traits (proliferation, adhesion, invasion and transendothelial migration) in melanoma and breast cancer ce...

Cancer immunotherapy refers to any intervention that leverages the immune system to eliminate a malignancy. Successful cancer immunotherapies generate an anti-cancer response that is systemic, specific, and durable and overcome to the primary limitations of traditional cancer treatment modalities. In this review paper, the effective methods in immune system to treat cancer, such as immunosuppre...

PURPOSE To investigate the occurrence of other primary malignancies before and after diagnosis of uveal melanoma in a Swedish population. METHODS In the Swedish Cancer Registry 2995 patients with uveal melanoma were notified during the period 1960 to 1998. In the same registry, a search for additional malignancies among these patients was performed. A matched case-control study with 2,916 pat...

Melanoma is a fatal type of skin cancer; the fury spread results in high fatality rate when malignancy not treated at an initial stage. The patients’ lives can be saved by accurately detecting cancer A quick and precise diagnosis might help increase patient’s survival rate. It necessitates development computer-assisted diagnostic support system. This research proposes novel deep transfer learni...

Skin cancer is a significant health problem. More than 123,000 new cases per year are recorded. Melanoma the most popular type of skin cancer, leading to more 9000 deaths annually in USA. disease diagnosis getting difficult due visual similarities. While common form other pathology types also fatal. Automatic melanoma screening systems will be useful identifying those cancers appropriately. Adv...

Skin cancer is the most common form of cancer in North America, and melanoma is the most dangerous type of skin cancer. Melanoma originates from melanocytes in the epidermis and has a high tendency to develop away from the skin surface and cause metastasis through the bloodstream. Early diagnosis is known to help improve survival rates. Under the current diagnosis, the initial examination of th...