OBJECTIVE To compare the opioid sparing effect of meloxicam, diclofenac, and placebo after abdominal hysterectomy. METHODS This study was conducted at the Riyadh Military Hospital, Riyadh, Kingdom of Saudi Arabia from February 2004 to November 2006. Women of American Society of Anesthesiologist's classification I or II of ages 25-60 years scheduled for abdominal hysterectomy were included. Th...

Specially engineered drug particles can solve solubility and formulation problems, which are major challenges for the pharmaceutical industry. Particle size reduction of poorly water soluble drugs results in increased dissolution rate and higher bioavailability or better processability as demonstrated in previous studies [1, 2]. High-pressure homogenization can be used to decrease particle size...

Treatment modalities for desmoid tumors have been changed because of the high recurrence rate, even after wide resection, and some cases experience spontaneous self-regression during clinical course. The treatment modality in our institutions before 2003 was surgical resection with wide surgical margin, however, meloxicam, which is a NSAID and a selective COX-2 inhibitor has been applied consec...

Meloxicam is a Non-Steroidal Anti-Inflammatory Drug (NSAID) given to humans and animals treat inflammation that most widely prescribed. The use of meloxicam not in accordance with the dose long term will cause toxic effect meloxicam. can trigger oxidative stress has mechanism inhibition prostaglandin synthesis affect hormonal regulation male reproduction. purpose this study was analyze potentia...

Pain associated with lameness on farm is a negative affective state and has a detrimental impact on individual farm animal welfare. Animal pain can be managed utilizing husbandry tools and through pharmacological approaches. Nonsteroidal anti-inflammatory drugs including meloxicam and flunixin meglumine are compounds used in many species for pain management because they are easy to administer, ...

Objective- Evaluate analgesic effect of meloxicam and tramadol following dental extractions in cats. Design-Experimental study Animals-20 DSH cats who were diagnosed with 3rd or 4th stage of periodontal disease at their third mandibular premolar were entered the study in order to perform surgical dental extraction. Procedure-A blood sample was taken prior to surgery to assess...

Development and evaluation of Meloxicam solid dispersion loaded buccal patchesMohammed Jafar, Sadath Ali

BACKGROUND Celecoxib and meloxicam are classified as cyclooxygenase (COX)-2 selective inhibitors. The Drug Safety Research Unit monitored the post marketing safety of these drugs in England using the non-interventional observational cohort technique of Prescription-Event Monitoring (PEM). OBJECTIVES To compare the incidence rates of selected thromboembolic (TE) (cardiovascular, cerebrovascula...

Spontaneously occurred canine mammary tumours (55) were treated with chemotherapy (Methotrexate), combination chemotherapy with COX-2 inhibitor (Meloxicam) and by surgical therapy. In chemotherapy groups Hb and TEC values reduced significantly (P<0.05) from the base line value at 3rd week of therapy. Histologically, benign and malignant mixed mammary tumours were predominant. Methotrexate and C...