The serotonin 2C receptor (5-HT(2C)R)-a key regulator of diverse neurological processes-exhibits functional variability derived from editing of its pre-mRNA by site-specific adenosine deamination (A-to-I pre-mRNA editing) in five distinct sites. Here we describe a statistical technique that was developed for analysis of the dependencies among the editing states of the five sites. The statistica...

Enforcement of global cooperation urges the rapid growth of cooperative work. As a typical application of it, cooperative editing is widely used in many fields gradually, especially in knowledge intensive application. Workflow is a kind of automation technology by predefined process rules and tasks. It can bring us clarity in process control and management, which are two important facets in coo...

Alternative splicing and adenosine to inosine (A to I) RNA-editing are major factors leading to co- and post-transcriptional modification of genetic information. Both, A to I editing and splicing occur in the nucleus. As editing sites are frequently defined by exon-intron basepairing, mRNA splicing efficiency should affect editing levels. Moreover, splicing rates affect nuclear retention and wi...

RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum, (c) the C-to-U substitution editing of the ma...

objective(s): there is controversial evidence about the effect of methamphetamine (meth) on spatial memory. we tested the time- dependent effects of meth on spatial short-term (working) and long-term (reference) memory in meth –sensitized and withdrawn rats in the morris water maze. materials and methods: rats were sensitized to meth (2 mg/kg, daily/5 days, sc). rats were trained in water maze ...

abstract aim and background: evaluation of cognition is fundamental for every comprehensive epilepsy program. we sought to conduct this study to assess memory state of patients with refractory temporal lobe epilepsy before decision for epilepsy surgery. method and materials: in a case-control study, 20 patients with right temporal lobe epilepsy and 20 patients with left temporal lobe epilepsy w...

Considerable progress has been made recently in the understanding of the cellular and molecular mechanisms that underlie the coupling between neuronal activity and glucose utilization by the brain. A central role in this coupling is played by astrocytes, which are strategically positioned through (a) processes that largely ensheath synapses and express receptors and reuptake sites for various n...