Patients who are already diagnosed with cutaneous melanoma are at increased risk of developing another primary melanoma. The occurrence of multiple primary melanoma is a rare phenomenon, varying in frequency, with an estimated incidence ranging from 0.2% to 8.6%. The authors are presenting data on the patients with multiple primary melanoma from the Croatian Referral Melanoma Centre. The clinic...

BACKGROUND The early detection of lymph node metastases may have important prognostic and therapeutic implications in melanoma patients. The purpose of this study was to investigate whether specific clinical and/or dermoscopic features could be "in vivo" predictors of sentinel lymph node (SLN) positivity in melanomas >1 mm thick. MATERIALS AND METHODS Five Italian centres (Istituto Dermopatic...

BACKGROUND AND PURPOSE Contrast-enhanced fluid-attenuated inversion recovery (FLAIR) imaging has been reported to have higher sensitivity for detecting leptomeningeal disease compared with contrast-enhanced T1-weighted MR imaging. The purpose of this study was to compare contrast-enhanced T1-weighted MR images with fat suppression to contrast-enhanced FLAIR images to determine which sequence wa...

Published accounts of tuberculous meningitis usually include intracranial tumour in the differential diagnosis. However, the two conditions are only likely to be confused when tuberculous meningitis is complicated by a tuberculoma or when there is diffuse infiltration of the subarachnoid space by malignant cells. As the latter causes an increase in both the cell and protein content of the cereb...

OBJECTIVES To investigate the spectrum of growth rates in melanomas and to identify clinical associations of rapidly growing melanomas. DESIGN Clinical interview, skin examination, and pathology review. SETTING Three tertiary melanoma referral centers and 2 private dermatology practices. PATIENTS A total of 404 consecutive patients with invasive primary cutaneous melanomas. MAIN OUTCOME...