The NF2 tumor suppressor gene, located in chromosome 22q12, is involved in the development of sporadic meningiomas of the nervous system. In order to evaluate the role of the NF2 gene in sporadic meningiomas, we analyzed the entire coding regions of the NF2 gene in a group of 42 sporadic meningiomas: 17 meningothelial, 11 transitional, 11 fibrous, one secretory, one atypical, and one malignant ...

Download pose: Meningiomas are the most common central nervous system tumors in the population of age d older. WHO defines three grades predictive of the risk of recurrence. Clinical data supporting ogic malignant progression of meningiomas are sparse and underlying molecular mechanisms t clearly depicted. erimental Design: We identified genetic alterations associated with histologic progressio...

OBJECTIVE To document and critically analyse the impact of the revised WHO 2000 histological classification for meningiomas on postoperative radiotherapy/radiosurgery indications and MRI follow up protocols. METHODS The current (2000) WHO classification was used to grade 57 meningiomas treated surgically at one institution. These had been reviewed previously in 1999. All German neurosurgical ...

119 deficit are most likely to occur in dorsal tumor cases. The psammomatous type of tumor can be removed piecemeal. But the total calcification type of tumor should sometimes be removed piecemeal to protect the spinal cord. In our case series, calcified meningiomas were pathologically diagnosed in all of the patients, or the tumor could not be confirmed as ossified meningiomas because the diag...

Meningiomas are central nervous system neoplasms derived from arachnoid cap cells. They are the second most common brain tumors after gliomas, but are rare in children. Furthermore, meningiomas exhibit different behavior in this age group. From 1997-2007, 7 children with brain meningiomas were treated at the Department of Neurosurgery, Brazilian National Cancer Institute, Rio de Janeiro, Brazil...

Background & Objective: Meningiomas are the most frequently encountered primary non-glial tumors of the central nervous system (CNS). The Ki67 labelling index (Ki67LI) is a proliferation marker that may prove useful in determining the histological grade. This study aims at: 1) Studying the frequency, grade and histomorphological spectrum of meningiomas, 2) Evaluating 20 histolo...

Abstract Background Meningiomas are considered the most common primary intracranial neoplasms. The surgical resection is main curative therapy. Evaluation of meningioma consistency and vascularity important before surgery to be aware about difficulties that neurosurgeon will face during resection, possibility total determine which equipment suitable for surgery. purpose this study was identify ...

Abstract YAP1 is a transcriptional co-activator and oncogene under the control of Hippo Signaling Pathway. Functional inactivation Pathway tumor suppressors, including NF2, are frequent events in human cancers. Meningiomas most common primary brain tumors, large percentage exhibit heterozygous loss chromosome 22 (harboring NF2 gene) functional remaining gene copy, implicating oncogenic YAP acti...

Abstract Background Histologically confirmed meningiomas in first year of life are quite rare. However, review of the sporadic cases in the literature reported meningioma in infants. Those have unique features in common. Case presentation An 11 month-old Iranian male infant presented with a several weeks history of decrease in movement of his right sided upper and lower extremities. Brai...

Meningiomas are the most common primary intracranial tumor thought to derived from arachnoidal cap cells in meningeal coverings of spinal cord and brain. The current WHO classification, published 2016, includes nine different subtypes grade 1 meningiomas, three 2 3 meningiomas. Metaplastic meningioma is a rare variant which shows focal or diffuse mesenchymal tissue component. Xanthomatous has f...