PURPOSE The aim of this multi-center study was to assess the diagnostic capability of visual assessment in L-methyl-11C-methionine positron emission tomography (MET-PET) for differentiating a recurrent brain tumor from radiation-induced necrosis after radiotherapy, and to compare it to the accuracy of quantitative analysis. METHODS A total of 73 brain lesions (glioma: 31, brain metastasis: 42...

AIM To evaluate the benefits of initiating insulin at an earlier versus later treatment stage, and regimens with/without sulfonylurea (SU). METHODS Pooled analysis of 11 prospective randomized clinical trials, including 2171 adults with uncontrolled type 2 diabetes initiating insulin glargine following a specific titration algorithm. Clinical outcomes were glycated haemoglobin A1c (HbA1c) red...

aim and background: meta-cognitive therapy is based on the principle that meta-cognitive is very important for understanding the way of cognition function and the way of producing our conscious experience about ourselves and the world around us. in this research it has been tried to study the effectiveness of this kind of treatment in improving depression patients. methods and materials: this c...

The mechanism of protein chain initiation has been investigated in a cell-free amino acid incorporation system from wheat embryos dependent on tobacco mosaic virus RNA. Analysis of the N-termini of the labeled peptide products of short-term incubations showed the presence of unblocked methionine. In addition, methionyl-tRNA (Met-tRNA) could be bound to ribosomes at 1.3 mM Mg(++) in a reaction r...

Extranodal spread (ENS) in patients with head and neck squamous cell carcinoma (HNSCC) can greatly influence the prognostic outcomes. However, the relative risks of ENS in the primary (1st) and secondary (2nd) metastatic nodes (mets) are not well documented. We retrospectively analyzed the hazard ratios (HRs) of ENS in the 1st and 2nd mets from 516 HNSCC patients who had undergone primary tumor...

Clear cell adenocarcinoma of the ovary (OCC) is a chemo-resistant tumor with a relatively poor prognosis and is frequently associated with endometriosis. Although it is assumed that oxidative stress plays some role in the malignant transformation of this tumor, the characteristic molecular events leading to carcinogenesis remain unknown. In this study, an array-based comparative genomic hybridi...

Activation of the c-Met receptor promotes intracellular signaling that is often synergistic, complementary, and, at times, redundant to that of other receptor tyrosine kinases (RTKs). It is therefore not surprising that the cellular processes induced by c-Met share many common features with other RTKs, i.e., anti-apoptosis, proliferation, and angiogenesis. However, 2 important phenotypes appear...

Receptor tyrosine kinases play important roles in the biology of many tumor cell types. In approximately 10% of non-small cell lung cancer (NSCLC) patients mutational activation of the epidermal growth factor receptor (EGFR) results in tumor cells that are exquisitely addicted to signaling by this receptor. (1) Thus expression of mutant active EGFR but in general not wild-type EGFR predisposes ...

• Rd is endowed with the standard inner product (·, ·) and Euclidean norm ‖ · ‖. • Md×d(R) denotes the space of n× n real matrices. • When Rd = E ⊕ F is a splitting of Rd into complementary subspaces, we let πE//F denote the projection onto E, parallel to F ; that is, the range of πE//F is E, πE//F ◦ πE//F = πE//F , and kerπE//F = F . • For a subspace E ⊂ Rd, let πE denote the orthogonal projec...

A dynamic phenotypic change contributes to the metastatic progression and drug resistance in malignant melanoma. Nevertheless, mechanisms for a phenotypic change have remained to be addressed. Here, we show that Met receptor expression changes in a cell-autonomous manner and can distinguish phenotypical differences in growth, as well as in metastatic and drug-resistant characteristics. In metas...