A better understanding of the molecular links between obesity and disease is potentially of great benefit for society. In this paper we discuss proposed mechanisms whereby bariatric surgery improves metabolic health, including acute effects on glucose metabolism and long-term effects on metabolic tissues (adipose tissue, skeletal muscle, and liver) and mitochondrial function. More short-term ra...

Liver defend the PAMPs or DAMPs via regulation of innate immunity through modulation of “TOLL LIKE RECEPTORS and NOD LIKE RECEPTORS” A breakdown of tolerance may induce in appropriate immune response leads to acute and chronic liver diseases like NASH/NAFLD thus considered as disorders of immune response. HFD is itself a basic component for generating metabolic disorders and major source for fo...

TADA, K., Y OSHIDA, T. and ARAAAWA, Ts. Free Amino Acid Pattern in the Liver from the Patients with Amino Acid Disorders: Postmortem Diagnosis of Inborn Errors of Amino Acid Metabolism. Tohoku J. exp. Med., 1970, 101 (3), 223-226 Free amino acid concentrations were determined in the liver biopsied or autopsied from the patients with amino acid disorder and from several controls. The results sho...

Non-alcoholic fatty liver disease (NAFLD) is emerging as a major health problem worldwide. NAFLD is a continuum of disease ranging from mild liver steatosis to severe steatohepatitis, which will ultimately lead to end-stage liver disease with high morbidity and mortality rates. This disorder is considered as a silent liver disease. The metabolic syndrome and its components are accounted as the ...

BACKGROUND Fine tuning of the Wnt/β-catenin signaling pathway is essential for the proper development and function of the liver. Aberrant activation of this pathway is observed in 20%-40% of hepatocellular carcinomas (HCC). Notum encodes a secreted Wnt deacylase that inhibits Wnt activity and thereby restricts the zone of activation of Wnt/β-catenin signaling. An important role of NOTUM has bee...

A change in hepatic blood flow caused by the hepatic arterial buffer response (HABR) occurs as fatty liver disease progress. The aim of this longitudinal cohort study was to investigate whether fatty liver with the HABR induces metabolic disorders. In 2009 and 2010, 494 (89.5%) participants were enrolled. The median follow-up duration was 5.0 (interquartile range, 3.9-6.0) years. The hazard rat...

Нарушения митохондриального бета-окисления жирных кислот - группа редких наследственных нарушений обмена веществ. Недостаточность длинноцепочечной 3-гидроксиацил КоА дегидрогеназы (LCHADD) одно из наиболее частых в странах Европы веществ группы дефектов кислот. Это заболевание характеризуется поражением печени, сердечной и скелетной мышц, частыми метаболическими кризами высокой смертностью детс...

The paper studies the influence of Raspol polysaccharide and fosprenil on chicken liver microstructure during vaccination against avian infectious bronchitis. response to integrated effects vaccine immunostimulants this period caused weakly expressed edema in perisinusoid spaces marked activation reticuloendothelium cells represented by increase Kupffer’s cells. On 28th day after vaccination, a...

This chapter introduces the history, definitional and semantic issues, spectrum and general importance of non-alcoholic fatty liver diseases (NAFLD). Nonalcoholic steatohepatitis (NASH) is a form of metabolic liver disease in which fatty change (steatosis) is associated with lobular inflammation, hepatocyte injury and/or hepatic fibrosis. It comprises a pathogenic link in the chain of NAFLD tha...

PURPOSE The goal of this study was the early diagnosis of ABCB11 spectrum liver disorders, especially those focused on benign recurrent intrahepatic cholestasis and progressive familial intrahepatic cholestasis. METHODS Fifty patients presenting neonatal cholestasis were evaluated to identify underlying etiologies. Genetic analysis was performed on patients suspected to have syndromic disease...