Metabolic disturbances and fat redistribution have been characterized in HIV-infected patients receiving combination antiretroviral therapy according to drug exposure and patterns of fat redistribution. In contrast, we investigated metabolic abnormalities in a well-characterized cohort of HIV-infected patients with clinical lipodystrophy in comparison with an established population of healthy c...

Metabolic syndrome (MetS) and cardiovascular disease is rapidly evolving.To treat hypertension, drug-classes with different glucometabolic effects are used but they have the potential for adverse metabolic effects. An open-label prospective crossover study was conducted to compare the PPARγ( peroxisome proliferative activated receptor γ) modulating activity of olmesartan (10 mg/day) and telmisa...

Obesity and related diabetes are important health threatening multifactorial metabolic diseases and it has been suggested that 25% of all diabetic patients are unaware of their patho-physiological condition. Biomarkers for monitoring and control are available, but early stage predictive biomarkers enabling prevention of these diseases are still lacking. We used the pig as a model to study metab...

OBJECTIVE We investigated the difference in metabolic parameters by waist circumference (WC) and body mass index (BMI) in a population of Korean men and women. METHOD We collected data on 69,535 Korean men and women and performed a cross-sectional analysis of the data. Study subjects were grouped by BMI and WC. We measured metabolic parameters for each group and compared the differences in th...

Telmisartan has been proposed to be a promising cardiometabolic sartan due to its unique peroxisome proliferator-activated receptor-gamma-inducing property. To determine whether telmisartan improves metabolic parameters in metabolic syndrome, we perform the first meta-analysis of randomized controlled trials (RCTs). MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were se...