The aim of the present clinical trial was to compare the long-term effect of EMDOGAIN treatment as an adjunct to modified widman flap (MWF) surgery with the effect of MWF and placebo treatment. The investigation was a placebo-controlled, randomized multicenter trial involving 33 subjects with 34 paired test and control sites. The protocol required 2 interproximal sites, appropriately separated,...

Single point incremental sheet metal forming is a sheet metal forming process that forms products without the complex dies and tools with low cost. In this study, the incremental sheet metal forming process has been experimentally investigated on the explosively-welded Al/Cu bimetal sheets. Also, the effects of process parameters, such as arrangement of layer`s bimetal, tool diameter and tool p...

In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon-fluorine bond formation has become a landmark achievement in fluorine chemistry. This rapidly growing research field has been the subject of some excellent reviews. Ou...

There have been no studies as yet that have evaluated how hemodialysis (HD) schedules affect the day of the week of hospitalization for cardiovascular diseases (CVDs) and infectious diseases (IDs), over a period of time. Herein, we performed a retrospective observational cohort study (1995-2014) evaluating 11,111 hospitalizations in 1,953 patients with end-stage renal disease, receiving HD 3 ti...

Introduction: A quantitative measurement of the myelin content of white matter (WM) can be used as a significant predictor of the prognoses of the clinically isolated syndrome and for earlier diagnosis of WM diseases such as multiple sclerosis (MS). One approach developed to provide valuable information on myelin content is to measure myelin water fraction (MWF) by analyzing T2 decay curves usi...

Workflow model performance analysis plays an important role in the research of workflow techniques and efficient implementation of workflow management. Instances dwelling times (IDT) which consist of waiting times and handle times in a workflow model is a key performance analysis goal. In a workflow model the instances which act as customers and the resources which act as servers form a queuing...

Macrophages, especially follicular dendritic cells, contribute to the pathogenesis of prion diseases by accumulating an abnormal isoform of prion protein (PrPSc), which is converted from the cellular isoform of prion protein (PrPC). As information on the function of PrPC in macrophages is limited, we have established a prion protein (PrP) gene (Prnp)-deficient macrophage cell line from the bone...

Many multi-channel dereverberation and noise reduction techniques such as the multi-channel Wiener filter (MWF) require an estimate of the late reverberation and noise power spectral densities (PSDs). State-of-the-art multi-channel methods for estimating the late reverberation PSD typically assume that the noise PSD matrix is known. Instead of assuming that the noise PSD matrix is known, in thi...

Purpose Postmortem MRI can be used to reveal important pathologies and establish radiology-pathology correlations. However, quantitative MRI values are altered by tissue fixation. Therefore, the purpose of this study was to investigate time-dependent effects of formalin fixation on MRI relaxometry (T1 and T2), diffusion tensor imaging (fractional anisotropy, FA; and mean diffusivity, MD), and m...

Less ergonomic work postures such as bending and squatting have the potential to pose risks. When muscles receive static loads repeatedly for a long time, it causes complaints of damage joints, ligaments, tendons commonly referred musculoskeletal disorders (MSDs) or injuries system. This study aimed determine level risk performed by workers in each activity using Rapid Entire Body Assessment (R...