Erythema multiforme (EM) is an uncommon acute mucocutaneous illness with target lesions primarily on the face and limbs. Slow-onset hypersensitivity reactions to infections (including herpes simplex virus mycoplasma pneumonia) medicines antibiotics, anticonvulsants, nonsteroidal anti-inflammatory drugs) cause EM. A 4-year-old male EM after taking metamizole, ampicillin, cloxacillin, unknown puf...

Abstract Background The optimal analgesic strategy for patients with acute pancreatitis (AP) remains unknown. present systematic review and meta-analysis aims to compare the efficacy of several modalities trialled in AP. Methods A search PubMed, MEDLINE EMBASE was conducted up until June 2021, according PRISMA Guidelines identify all randomised control trials (RCTs) comparing primary outcome me...

Case-report An 82 year-old man with hypertension and ischemic heart disease underwent an inguinal hernioplasty. Twenty hours after initiating PC administration in the surgery room, a slightly pruritic eruption suddenly appeared with multiple tender, oedematous and erythematous plaques on the trunk and extremities, associated to general malaise, headache and myalgia. He didn’t seek for medical c...

Paracetamol (acetaminophen) is one of the most popular over-the-counter analgesic and antipyretic drugs. Paracetamol is available in different dosage forms: tablet, capsules, drops, elixirs, suspensions and suppositories. Dosage forms of paracetamol and its combinations with other drugs have been listed in various pharmacopoeias. The combination of paracetamol with dipyrone is used as an antipy...

OBJECTIVES This study aimed to describe the mode of refeeding, frequency of intolerance, and related factors in mild acute pancreatitis (AP). METHODS We included all cases of mild AP between January 2007 and December 2009 in an observational, descriptive, and retrospective study. We analyzed demographic and etiological data, admission variables, treatment, refeeding mode, intolerance frequenc...

BACKGROUND AND GOAL OF STUDY After laparoscopic cholecystectomy, patients have moderate pain in the early postoperative period. Some studies shown beneficial effects of subcostal transversus abdominis plane block on reducing this pain. Our goal was to investigate influence of subcostal transversus abdominis plane block on postoperative pain scores and opioid consumption. MATERIALS AND METHODS...

Pain represents a complex experience which can be approached by various medicines. Non-opioid and opioid analgesics are the most common drugs used to manage different types of pain. The increased attention nowadays to pain management entailed concomitantly more frequent adverse drug reactions (ADRs) related to analgesic use. Drug-drug interactions can be sometimes responsible for the adverse ef...