Due to the heterogeneous nature of breast cancer, metastasis organotropism has been poorly understood. This study assessed specific cancer-related gene expression changes occurring with metastatic cancer recurrence distant organs compared non-metastatic cancer. We found that several secreted mediators encoding genes notably, LCN2 and S100A8 overexpressed at site spine (LCN2, 5-fold; S100A8, 6-f...

a 57-year-old male with history of prostatectomy, cyctectomy, cecal urinary diversion for invasive prostate cancer and with a recent rise in psa level, was referred for bone scintigraphy to rule out osseous metastatic disease. an interesting finding was abnormal tracer accumulation throughout the large bowel, which was proved to be due to urinary diversion.

In vivo studies of the metastatic process are severely hampered by the fact that most human tumor cell lines derived from highly metastatic tumors fail to consistently metastasize in immunodeficient mice like nude mice. We describe a model system based on a highly immunodeficient double knockout mouse, Rag2-/-;Il2rg-/-, which lacks T, B and NK cell activity. In this model human metastatic HER-2...

metastatic tumors account for 1% of all oral malignancies. metastasis to jaw bones is common, particularly in the mandible, rare in the oral soft tissues, and account for only 0.1% of oral malignancies. the majority of metastatic cases (70%) reported in the literature have primary tumors located in the lung, breast, kidney, and colon. metastasis is a biological complex process that involves det...

Summary With the development of various targeted therapies in breast cancer, detection biomarkers for predicting treatment efficacy gains importance. definition intrinsic subtypes, cancer has paved way personalized treatment. Already known and recently recognized targets play an important role both metastatic early cancer. As a result, molecular profiling is becoming part diagnostic work-up. No...

aim : to create an orthotopic hepatoma model with local metastasis monitored with ultrasound could be created as a platform for testing new treatments.   background : hepatoma accounts for 25% of liver tumors in children with poor overall survival. intraabdominal metastasis are present in 35% of patients at time of diagnosis.  we hypothesized that an orthotopic tumor model with local metastasis...

Anal cancer is a relatively rare gastrointestinal tumor with roughly 7,000 new cases per year. Metastatic anal cancer as an initial presentation occurs in 10-20% of the patients. Treatment for localized disease is well established with concurrent chemoradiation (CCR) therapy as the standard of care; however, metastatic anal cancer remains a therapeutic challenge. National Comprehensive Cancer N...

Introduction: Colon adenocarcinoma is one of the foremost causes of cancer mortality. Oral metastasis of colon adenocarcinoma is, however, rare and indicates an end-stage disease process.   Case Report: We report a case of a 69-year-old female with a gingival mass diagnosed with colon adenocarcinoma and liver metastasis after one year. A swelli...

BACKGROUND We used population-based data from the New South Wales Central Cancer Registry (CCR) to describe the patterns of progression to metastatic disease in Australian men diagnosed with non-metastatic prostate cancer. METHODS Data for all non-metastatic prostate cancer cases diagnosed 1993-2002 and followed to the end of 2007 were analysed. The outcome was progression to metastatic disea...

 ABSTRACT Carcinoma of the cervix is a common neoplasm and accounts for a considerable number of cervical diseases that lead to death in developing countries. In these countries early detection and improved methods of treatment have resulted in comparatively better control of the cancer and long survival however, invasive and metastatic disease still occurs. The authors present the case report ...