Water clear cells; they can be seen in many tumors such as germ cell tumors, kidney lymphomas, sarcomas, thymic carcinomas, parathyroid paraganglioma. They may primary or occur a result of metastatic conditions. Therefore, histopathologically differential diagnosis difficult confusing. Clinical findings, radiological findings and histopathological evaluation required for diagnosis. 
 Here,...

Oral cavity metastatic tumors derived from primary other corporal regions are rare, representing barely 1 % of all malignant tumors. Differential diagnosis these lesions is challenging due to the wide spectrum with similar clinical presentation and especially when presence a tumor goes undetected. We present case 55-year-old male painless in anterior maxillary region, vestibular gingiva palate,...

Materials and methods MicroRNA expression profiles were generated by microarray analysis (Agilent) of 70 samples from primary breast tumors with different clinical staging. Data were analyzed using bioinformatics software (R, Cluster and Tree View), which allowed sample discrimination (metastatic vs. non metastatic tumors) by hierarchical clustering of breast cancer expression signatures. We pe...

BACKGROUND Despite being the most common pelvic gynecologic malignancy in industrialized countries, no targeted therapies are available for patients with metastatic endometrial carcinoma. In order to improve treatment, underlying molecular characteristics of primary and metastatic disease must be explored. METHODOLOGY/PRINCIPAL FINDINGS We utilized the mass spectrometric-based mutation detect...

background: cd4+ and cd8+ t cells are the main types of lymphocytes in cell-mediated immunity and play a central role in the induction of efficient immune responses against tumors. the frequencies of t cell subtypes in the peripheral blood and tumor tissues, and draining lymph nodes (dln) can be considered as useful markers for evaluation of the immune system in cancers. methods: in this study,...

Objective. The purpose of this study was to investigate the clinical risk factors associated with adverse outcomes in cases of metastatic ovary tumors during a recent 20-year periods. Patients and methods. One hundred sixty-four patients with metastatic ovary tumors who was confirmed on pathologic diagnosis after surgery in three centers between January 1996 and December 2015. Clinical variable...

Previous NGS experiments showed that distinct parts of the same tumor different mutation profiles. Additionally, primary tumors and their metastases can differ in mutational pattern. In this study, we compare KRAS status between colorectal cancer tissue recurrent/metastatic sites. Four patients with metastatic adenocarcinoma were screened for mutations by Idylla automated testing on two tissues...

The extracellular matrix (ECM) is a major component of tumors and a significant contributor to cancer progression. In this study, we use proteomics to investigate the ECM of human mammary carcinoma xenografts and show that primary tumors of differing metastatic potential differ in ECM composition. Both tumor cells and stromal cells contribute to the tumor matrix and tumors of differing metastat...