LE TRAITEMENT D’ENTRETIEN À LA MÉTHADONE constitue une stratégie efficace de traitement de la dépendance aux opiacés. De nombreux obstacles, y compris les stigmates que la société impose aux consommateurs d’opiacés et aux patients qui prennent de la méthadone, limitent malheureusement l’accès à ce mode de traitement. Dans ce numéro (page 395), les Drs Mark Latowsky et Evelyn Kallen discutent de...

BACKGROUND Methadone Medical Maintenance (MMM) was implemented in 1983 to enable socially rehabilitated methadone patients to be treated in the offices of private physicians rather than in the traditional clinic system. Over a period of 15 years, 158 methadone patients who fulfilled specific criteria within the clinic system entered this program in New York City. Participating patients reported...

CONTEXT Methadone maintenance is an effective treatment for opioid dependence, yet its use is restricted to federally licensed narcotic treatment programs (NTPs). Office-based care of stabilized methadone maintenance patients is a promising alternative but no data are available from controlled trials regarding this type of program. OBJECTIVE To determine the feasibility and efficacy of office...

Objectives: This study presents the comparative safety and side effect profiles of buprenorphine and methadone, including gender relationships, from a clinical trial comparing buprenorphine and methadone in the outpatient treatment of opioid dependence. Methods: One hundred sixty-four opioid dependent volunteers age 18–50 years were randomized to buprenorphine (n = 84) or to methadone (n = 80) ...

Many clients who undergo methadone maintenance (MM) treatment for heroin and other opiate dependence prefer abstinence from methadone. Attempts at methadone detoxification are often unsuccessful, however, due to distressing physical as well as psychological symptoms. Outcomes from a MM client who voluntarily participated in an Acceptance and Commitment Therapy (ACT) - based methadone detoxifica...

CONTEXT Most research on heroin dependence treatments assesses short-term changes in patients' self-reported drug use. To our knowledge, long-term sustainability of changes in patients' drug use and associated hospital morbidity posttreatment have not been studied. OBJECTIVES To evaluate drug-related hospital morbidity in heroin users at 6 months and 3 1/2 years after receiving naltrexone imp...

BACKGROUND Due to potential proarrhythmic side-effects levo-alpha-Acetylmethadol (LAAM) is currently not available in EU countries as maintenance drug in the treatment of opiate addiction. However, recent studies and meta-analyses underline the clinical advantages of LAAM with respect to the reduction of heroin use. Thus a reappraisal of LAAM has been demanded. The aim of the present study was ...

background: in iran, methadone has been used for methadone maintenance treatment (mmt) as well as analgesic treatment in pain clinics. recently, there are some reports regarding accidental and intentional methadone poisonings and deaths. the aim of this study was to evaluate the trend of methadone poisonings and deaths during a 10-year period in tehran, iran. methods: this was a retrospective c...