BACKGROUND Genetic variability may influence methadone metabolism, dose requirements, and risk of relapse. OBJECTIVES To determine whether the CYP2B6*6 or ABCB1 (rs1045642) polymorphisms are associated with variation in methadone response (plasma concentration, dose, or response to treatment). METHODS Two independent reviewers searched Medline, EMBASE, CINAHL, PsycINFO, and Web of Science d...

the current preliminary study aimed to explore the reasons that a group of opiate-dependent patients reported for entry into opium tincture treatment (ott).through examinations of 52 qualitative focus group interviews with patients from six ott centers and 10 health providers (in key informant interviews) in tehran, this study highlights the factors that participants reported as the reasons ass...

BACKGROUND To determine, in a region of Switzerland, the duration of retention in opioid substitution treatments with methadone (OSTM), duration of treatment interruptions, probability of re-entry to treatment after a treatment interruption, and associated factors. METHODS A secondary analysis of registry-based data was performed with patients (n = 2880) registered in the methadone treatment ...

ôbjective: to investigate the pharmacokinetics (pk) and pk- pharmacodynamic (pd) relationship of methadone in a cohort of outpatients undergoing methadone maintenance treatment (mmt). methods: sixty male patients undergoing mmt with a mean ±sd methadone daily dosage of 58 ± 34 mg were enrolled in this study. â 5-ml blood sample was collected before the daily intake of methadone. âs a pd measure...

Background: The study of temperament and problem-solving styles in people with substance abuse is important in promoting the functions of prevention and treatment of this social problem. Therefore, the aim of this study was to compare the nature and problem-solving skills of methadone treated patients with buprenorphine treated patients.Methods: This study was performed on 62 patients and 54 pa...

Methadone maintenance treatment of opioid addiction was developed in 1965 and implemented in the United States as a form of opioid agonist treatment. In the 1970s, a system of federal regulation was imposed in response to reports of diversion of methadone into illicit channels. In 1993, the US government gave approval to LAAM as a second maintenance medication, and, in 2002, buprenorphine, a pa...

BACKGROUND AND OBJECTIVES Breastfeeding, a public health priority, improves outcomes for infants. Methadone is dispensed as a racemic mixture; R-methadone is the active enantiomer. Pharmacologic data for R-methadone in breastmilk could improve risk-benefit decision-making for treatment of lactating women. This study estimated infant exposure to R- and S-methadone via breastmilk by theoretic inf...

Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realit...

BACKGROUND Drug abuse is a problem that causes a wide array of social, emotional, and physical problems and involves both patients and the society. Helping the addicted has always been a priority for physicians and especially psychiatrists. The purpose of this prospective study was to compare the effects of methadone and naltrexone in general well-being of patients undergoing these treatments. ...