Two murine-derived anti-methamphetamine monoclonal antibodies were studied as potential pharmacokinetic antagonists of (+)-methamphetamine self-administration by rats. Intravenous administration of a 1 g/kg dose of the lower affinity [antibody equilibrium dissociation constant (K(d)) = 250 nM] monoclonal antibody (mAb) designated mAb6H8, 1 day before the start of several daily 2-h self-administ...

Methamphetamine abuse in young adults has long-term deleterious effects on brain function that are associated with damage to monoaminergic neurons. Administration of glial cell line-derived neurotrophic factor (GDNF) protects dopamine neurons from the toxic effects of methamphetamine in animal models. Therefore, we hypothesized that a partial GDNF gene deletion would increase the susceptibility...

While numerous studies examine methamphetamine use and associated risky sexual behaviors in HIV-uninfected individuals, few studies have surveyed HIV-infected individuals in the health care setting. To assess the frequency and trends of methamphetamine use, sexual activity, injection drug use, patient-provider communication, and medication adherence among HIV-infected persons in care, we admini...

INTRODUCTION: Methamphetamine (METH) is a major drug of abuse in the United States and in many countries throughout the world. Preclinical and clinical studies demonstrated significant neurotoxic effects and brain changes associated with the drug. However, few studies have evaluated morphometric changes associated with METH abuse [1-3]. We performed voxel based morphometry to determine whether ...

Abstract Background The misuse of illicit substances is associated with increased morbidity and mortality; thus, substance abuse a global health concern. Arabian Gulf region considered crossing point consumer drugs. However, lack laboratory-based research has limited the scientific assessment drug in region. Thus, an up-to-date analytical representation situation warranted. Methods We investiga...

drug abuse is considered as the most common poisoning in the world. stimulants agent especially amphetamines and methamphetamines are among important abused substances. different types of neurologic, psychiatric, respiratory, gastrointestinal, and cardiogenic complications have been reported to be related to methamphetamine consumption. some of these substances could cause dysrhythmias which is...

BACKGROUND Psychotic disorder due to industrial drug, such as methamphetamine addiction, is one of the important causes for referral to psychiatric hospital. Psychotic symptoms in these patients are varied. A group of researchers believe that methamphetamine-induced psychosis is completely similar to schizophrenia. Others believe that at least some cases of permanent psychotic clinical manifest...