Staphylococcus aureus bacteremia is associated with high mortality and morbidity, requiring prompt and appropriate antimicrobial treatment. Therefore, it is important to detect methicillin-resistant S. aureus (MRSA) rapidly from blood cultures. Two immunochromatographic tests, BinaxNow S. aureus and BinaxNow PBP2a, were directly applied to 79 Bact/Alert bottles that were positive for Gram posit...

Trends in Staphylococcus aureus infections are not well described. To calculate incidence in overall S. aureus infection and invasive and noninvasive infections according to methicillin susceptibility and location, we conducted a 10-year population-based retrospective cohort study (1999-2008) using patient-level data in the Veterans Affairs Maryland Health Care System. We found 3,674 S. aureus ...

Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium responsible for several difficult-to-treat infections in humans. It may be named multidrug-resistant S. aureus or Oxacillin-resistant S. aureus (ORSA). MRSA is a strain of S. aureus that developed resistance to β-Lactam antibiotics, including Penicillins, which include (Methicillin, Dicloxacillin, Nafcillin, Oxacillin, etc.) and ...

There are increasing numbers of reports of community-acquired Staphylococcus aureus being resistant to methicillin. The present study was undertaken as no such reports are available for the developing nations. In a prospective study, between June to December 2001, at the Karnataka Institute of Medical Sciences, Hubli, Karnataka, India, methicillin-resistant S. aureus (MRSA) isolates were tested...

Despite reports of high colonization rates of ST398 livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) among pigs and pig farmers, the incidence of LA-MRSA infection in the general population in Canada appears to be rare in comparison to that in some European countries. In this study, the complete genome sequence of a Canadian representative LA-MRSA isolate (08BA02176) f...

Methicillin-resistant S. aureus emerged in recent decades to become a leading cause of infection worldwide. Colonization with MRSA predisposes to infection and facilitates transmission of the pathogen; however, available regimens are ineffective at preventing MRSA colonization. Studies of human nasal flora suggest that resident bacteria play a critical role in limiting S. aureus growth, and pro...

Methicillin was introduced in 1959 to treat penicillin-resistant S. aureus infection, however Methicillin-resistant S. aureus (MRSA) was reported 2 years later (1). The most common organism identified in acute infective endocarditis (AIE) is still S. aureus associated with increased hospital mortality, morbidity and hospitalization. In Germany the proportion of MRSA among S. aureus microbiologi...

background methicillin-resistant staphylococcus aureus (mrsa) remains a significant public health problem and treatment challenge. objectives this study was conducted to determine the frequency, molecular types, and drug resistance of s. aureus isolated from nasal carriers in two teaching hospitals (hajar and kashani) in shahrekord, southwestern iran. methods in this cross-sectional study, 262 ...

INTRODUCTION The introduction of methicillin in 1959 was a ground-breaking achievement in the war against penicillin-resistant Staph ylococcus aureus. Methicillin was developed to overcome the primary mode of resistance found with resistant strains of S. aureus, inactivation of penicillin by beta-lactamase. In 1961, this monumental achievement was overshadowed by the discovery of several strain...

Multiple methicillin-resistant Staphylococcus aureus (MRSA) clones carrying type IV staphylococcal cassette chromosome mec were identified in the community-acquired MRSA strains of both the United States and Australia. They multiplied much faster than health-care-associated MRSA and were resistant to fewer non-beta-lactam antibiotics. They seem to have been derived from more diverse S. aureus p...