Graves’ Disease (GD) is the most common form of hyperthyroidism. It affects 3% female patients and 0.5% male usually between age 30-60. cause 80% hyperthyroid cases in USA. The pathogenesis disease complex autoimmunity plays a key role. antibodies stimulating thyrotropin receptor (TRAb) lead to uncontrolled Thyroid-stimulating Hormone (TSH) overproduction thyroid hormones from overactive gland....

The treatment of hyperthyroidism with antithyroid drugs can cause a significant side effect in 0.2 to 0.3% of the cases: agranulocytosis. Infectious complications caused by this condition affect mainly the throat, and tonsillitis is one of its manifestations. The present study reported the case of a female patient, 33 years old, manifesting odynophagia and fever resistant to many antibiotics. T...

OBJECTIVE: To evaluate the changes in clinical parameters and in the approach to patients submitted to radioiodine therapy for Graves’ disease. MATERIALS AND METHODS: Dossiers of 226 patients submitted to radioiodine therapy for Graves’ disease in the period between January 1990 and December 2001 were retrospectively evaluated. For the purposes of statistical analysis, the 12-year period was su...

INTRODUCTION Propylthiouracil (PTU) has been used for the treatment of hyperthyroidism since the 1940s, but over the years reports of significant hepatotoxicity have come forth, particularly in children. This led to a black box warning being issued by the US FDA in 2009, followed by a similar warning by the European Medicines Agency and the United Kingdom Medicines and Healthcare Regulatory Age...

Among the causative factors for acute pancreatitis, adverse drug reactions are considered to be rare. The diagnosis of drug-induced pancreatitis (DIP) is challenging to establish, and is often underestimated because of the difficulties in determining the causative agent and the need for a retrospective re-evaluation of the suspected agent. We present the case of an 80-year-old woman who present...

Graves’ disease is the most common cause of hyperthyroidism during pregnancy. Propylthiouracil (PTU) is the treatment of choice due to its relative safety during pregnancy compared to methimazole. However, rarely, PTU causes serious complications like hepatitis. We report a case of hepatitis possibly related to PTU during pregnancy complicated by thyrotoxicosis.