Purpose: Infertility is described as unexplained when all of the tests a basic infertility evaluation return within normal limits and present in 15% infertile couples. Some studies indicate that there an association between methylenetetrahydrofolate reductase (MTHFR C677T A1298C) mutations male or female grown adults. The objective this study was to analyze distributions MTHFR’s A1298C genotype...

Background The methylenetetrahydrofolate reductase (MTHFR) is thought to be involved in the development of nonsyndromic cleft lip with or without cleft palate (NSCL/P). However, conflicting results have been obtained when evaluating the association between maternal MTHFR C677T and A1298C polymorphisms and the risk of NSCL/P. In light of this gap, a meta-analysis of all eligible case-control stu...

Elevated plasma homocysteine (Hcy) is one of the suggested risk factors for endothelial dysfunction. There is evidence of association between raised plasma Hcy and an increased risk of developing peripheral arterial disease. A causal relationship, however, has not been established. In this report, a 37-year old male patient with the complaints of intermittent hand pain is presented. Brachial ar...

Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction (MI). Single nucleotide at any one amino acid sequences can result diseased state. A single gene exhibit genetic more than position giving rise to different variants. angiotensinogen (AGT) M235T, AGT T174M, angiotensin-1-converting enzyme (ACE) I/D, endothelial nitric oxide synthase (eNOS), methyl...

Introduction: One factor known to cause thrombophilia in women with unexplained recurrent spontaneous abortion (RSA) is C677T polymorphism of methylenetetrahydrofolate reductase gene. This study aimed to determine the association between RSA and MTHFR C677T polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with previous history of two or more consecutive unexpla...

background: to assess whether the c677t and a1298c mutations in the methylenetetrahydrofolate reductase (mther) gene are associated with recurrent abortion (ra), we determined the frequencies of the t677 and c1298 mutations in patients and controls. materials and methods: mutations were determined by a rflp-pcr method in 53 patients and 61 matched controls. results: the frequencies of t alleles...

We present the case of a 28-year-old woman who was admitted to our cardiology unit for acute coronary syndrome. Her history was notable for cardiovascular disease familiarity, active smoking, and oral contraceptive use. On further analysis, she was noted to have thrombophilic polymorphisms involving the plasminogen activator inhibitor (PAI), angiotensin-converting enzyme (ACE), and methylenetet...