Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...

Carbosulfan (2,3-dihydro-2,2dimethyl-7-benzofuronyl [(dibutyl amino) thio] methyl] a carbamate insecticide and acaricide was administered orally at an effective dose of 48 mg/kg/day to albino mice for 5, 10, 20 and 30 days .Control mice received similar quantities of olive oil. Daily body weights were recorded and mice were sacrificed after 24 hours after the terminal exposure. The histologic e...

Objective: To investigate the protective effects of Haeganjeon on a thioacetamide (TAA)-induced liver fibrosis mouse model and to determine Haegan-jeon signaling pathway.Methods: Mice were randomly divided into 4 groups: Normal group (Nor), TAA-induced (Con), administered 50 mg/kg silymarin (S50), 200 (H200). The was established by intraperitoneal injection with TAA three times week for 8 weeks...

Alcoholic liver disease occurs due to chronic, heavy drinking and is driven both by metabolic alterations and immune cell activation. Women are at a higher risk than men for developing alcohol induced liver injury and this dimorphism is reflected in animal models of alcoholic liver disease. The importance of adipose tissue in alcoholic liver disease is emerging. Chronic alcohol consumption caus...

background and objectives: multiple sclerosis is an inflammatory disease of the central nervous system. this is due to migration of peripherally activated lymphocytes to central nervous system leading to inflammatory lesions. however, liver has an anti-inflammatory microenvironment. myelin expression in the liver of transgenic mice suppresses inflammatory lesions within central nervous system. ...

Background and Aims: Adenovector gene transfer induces inflammatory response that finally leads to vector removal from delivered site. The effect of hydrodynamic pre-injection on Adenovector mediated liver inflammation remained elusive. Materials and Methods: Different mice groups were pre-treated by hydrodynamic saline, dexamethasone or nothing prior to Adeno-Luciferase administration. Their s...

A 15-week gestation female fetus was delivered for unexplained intrauterine fetal death. The fetus weighed 125 g and had a crown heel length of 17 cm. Clinical maternal history was unremarkable, with a regular course of gestation until then. At autopsy, no somatic and/or visceral malformations were disclosed. All thoracic and abdominal organs showed initial autolytic changes, the liver was incr...

Non-alcoholic steatohepatitis (NASH) is a common complication in patients with psoriasis. It has been assumed that inflammatory links exist between NASH and In the present study, we investigated linkages using mouse models. Mice received intraperitoneal injection of streptozotocin at 2 days age were fed high-fat diet for 10 weeks, which used as non-obese model. Imiquimod (IMQ) was applied to ea...

Zinc oxide (ZnO) nanoparticles have received growing attention for several biomedical applications. Nanoparticles proposed for these applications possess the potential to interact with biological components such as the blood, cells/ tissues following their administration into the body. Hence we carried out in vivo investigations in Swiss Albino Mice to understand the interaction of ZnO nanorods...

the purpose of this study was to examine the acute and sub-acute effects of diazinon onhistopathological parameters of liver tissue and blood level of hepatic enzymes of male commonfrog (rana ridibunda). frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):control and treatment groups with 30, 60, 90 and 120 μg/l diazinon in water for one day or oneweek. hepatic enzymes containi...