A wealth of time series of microarray measurements have become available over recent years. Several two-sample tests for detecting differential gene expression in these time series have been defined, but they can only answer the question whether a gene is differentially expressed across the whole time series, not in which intervals it is differentially expressed. In this article, we propose a G...

Clustering is an important technique in microarray data analysis, and mining three-dimensional (3D) clusters in gene-sample-time (simply GST) microarray data is emerging as a hot research topic in this area. A 3D cluster consists of a subset of genes that are coherent on a subset of samples along a segment of time series. This kind of coherent clusters may contain information for the users to i...

microarray data have an important role in identification and classification of the cancer tissues. having a few samples of microarrays in cancer researches is always one of the most concerns which lead to some problems in designing the classifiers. for this matter, preprocessing gene selection techniques should be utilized before classification to remove the noninformative genes from the microa...

MOTIVATION Following the advent of microarray technology in recent years, the challenge for biologists is to identify genes of interest from the thousands of genetic expression levels measured in each microarray experiment. In many cases the aim is to identify pattern in the data series generated by successive microarray measurements. RESULTS Here we introduce a new method of detecting patter...

Microarray data stores the measured expression levels of thousands genes simultaneously which helps researchers to get insight into biological and prognostic information. Cancer is a deadly disease that develops over time involves uncontrolled division body cells. In cancer, many are responsible for cell growth division. But different kinds cancer caused by set genes. So be able better understa...

1Department of Electrical and Computer Engineering, UAB School of Engineering, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294-4461, USA 2Department of Biostatistics, University of Alabama at Birmingham, 1665 University Blvd, Birmingham, Al 35294-0022, USA 3Statistics and Epidemiology Unit, RTI International, Oxford Building, Suite 119, 2951 Flowers Road South...

MOTIVATION Periodic processes play fundamental roles in organisms. Prominent examples are the cell cycle and the circadian clock. Microarray array technology has enabled us to screen complete sets of transcripts for possible association with such fundamental periodic processes on a system-wide level. Frequently, quite large numbers of genes have been detected as periodically expressed. However,...

The analysis of microarray data from time-series experiments requires specialised algorithms, which take the temporal ordering of the data into account. In this paper we explore a new architecture of Bayesian classifier that can be used to understand how biological mechanisms differ with respect to time. We show that this classifier improves the classification of microarray data and at the same...

Periodic processes play fundamental roles in organisms. Prominent examples are the cell cycle and the circadian clock. Microarray array technology has enabled us to screen complete sets of transcripts for possible association with such fundamental periodic processes on a system-wide level. Frequently, quite a large number of genes has been detected as periodically expressed. However, the small ...