نتایج جستجو برای: microfluidic biochips

تعداد نتایج: 18179  

Journal: :Analytical chemistry 2004
David Erickson Xuezhu Liu Ulrich Krull Dongqing Li

Biosensors and more specifically biochips exploit the interactions between a target analyte and an immobilized biological recognition element to produce a measurable signal. Systems based on surface nucleic acid hybridization, such as microarrays, are particularly attractive due to the high degree of selectivity in the binding interactions. One of the drawbacks of this reaction is the relativel...

2009
Helene Lalo

Enhancement of biochips and biochips scanners is a crucial issue in the actual industry that needs more sensitive and less expensive molecular analysis tools. In this aim, several points have to be re-examined: detector sensitivity, chip density, labeling. In this perspective, we have developed several different techniques based on soft lithography to pattern molecules. We also have developed a...

Journal: :Technology 2015
U Hassan B Reddy G Damhorst O Sonoiki T Ghonge C Yang R Bashir

Complete blood cell counts (CBCs) are one of the most commonly ordered and informative blood tests in hospitals. The results from a CBC, which typically include white blood cell (WBC) counts with differentials, red blood cell (RBC) counts, platelet counts and hemoglobin measurements, can have implications for the diagnosis and screening of hundreds of diseases and treatments. Bulky and expensiv...

2011
Rohit Chand You-Cheol Jang Sandeep Kumar Jha Yong-Sang Kim

Microfabricated biochips are very efficient platforms for analysis of biologically important molecules such as DNA, RNA, enzymes, antibodies etc. These devices requires sample in micro/nano volume and produces faster and better results. For these reasons, we fabricated a simple, disposable microfluidic device for amperometric detection of DNA intercalated with methylene blue redox dye. The devi...

2003
Jagannathan Narasimhan Ian Papautsky

In this paper, we describe a simple and rapid method of fabricating hot embossing tools using polydimethylsiloxane (PDMS), which are then used to rapidly fabricate microchannels in polymethylmethacrylate (PMMA). A negative photoepoxy SU-8 or thick positive photoresist AZ4620 on silicon was used for molding during PDMS casting. Fabrication time of these PDMS tools was considerably less than thos...

2013
Feriel S. Hamdi Olivier Français Marion Woytasik Elisabeth Dufour-Gergam Bruno Le Pioufle

This paper deals with the transition of the dielectric properties of cells as a marker of their permeabilization. A demonstration of the transition between positive and negative DiElectroPhoresis (DEP) as a reaction to electroporation pulses is achieved in a microfluidic device. Electropermeabilization of cell membrane is broadly used in cell biology for electrotransfert of genes and other mole...

2010
Thomas Mangeat Alexandre Berthier Céline Elie-Caille Maud Perrin Wilfrid Boireau Christian Pieralli Bruno Wacogne

We report Gold/Silica biochips for low cost biosensor devices. Firstly, the study of biochemical interactions on silica by means of Surface Plasmon Resonance (SPR) is presented. Secondly, Gold/Silica biochips are employed to reduce the strong quenching that occurs when a fluorophore is close to the gold surface. Furthermore, the control of the Silicalike thickness allows optimizing the distance...

Journal: :Journal of Biomolecular Screening 2002

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