OBJECTIVE To investigate the risk factors of symptomatic bradyarrhythmias in relation to β-blockers use. METHODS A hospital-based case-control study [228 patients: 108 with symptomatic bradyarrhythmias (cases) and 120 controls] was conducted in Sultanah Aminah Hospital, Malaysia between January 2011 and January 2014. RESULTS The mean age was 61.1 ± 13.3 years with a majority of men (68.9%)....

INTRODUCTION According to the convincing evidence, a decline in mortality rate has been achieved with beta-blockers in patients with an acute myocardial infarction and in post-infarction follow-up. In fact, there has been a clear reduction of sudden coronary death. The necessary condition for the efficiency of beta-blockers is an early use. They are also a medication of choice for angina after ...

Objective: The study was conducted to identify the prescribing practices in essential hypertension to find out prescribing patterns in elderly patients. Material and methods: A retrospective study was done to assess the pattern and prescription of antihypertensive drugs at Maharishi Markandeshwar Medical College and Hospital, Kumarhatti Solan (H.P) A total of 100 handwritten prescriptions of pa...

Single-dose administration of beta-adrenoceptor agonists produces bronchodilation and inhibits airway hyperresponsiveness (AHR), and is the standard treatment for the acute relief of asthma. However, chronic repetitive administration of beta-adrenoceptor agonists may increase AHR, airway inflammation, and risk of death. Based upon the paradigm shift that occurred with the use of beta-blockers i...

Major complications associated with cardiac surgery are still common and carry great prognostic significance. β-Blockers, statins, antiplatelets, and renin-angiotensin system (RAS) blockers are current medical interventions to prevent cardiovascular complications in cardiac surgery. Renin-angiotensin system blockers include angiotensin-converting enzyme inhibitors, angiotensin II receptor block...

Abstract Background In heart failure with mildly reduced ejection fraction (HFmrEF) European guidelines recommend the use of antineurohormonal therapies a low level evidence (IIb C) based on data from subgroup and post-hoc analyses randomized clinical trials (RCTs). Data large unselected real-world HFmrEF populations are lacking. Purpose To assess association between renin-angiotensin system in...

The COVID-19 pandemic has disrupted life throughout the world. Newly developed vaccines promise relief to people who live in high-income countries, although and expensive new treatments are unlikely arrive time help low-and middle-income countries. pathogenesis of is characterized by endothelial dysfunction. Several widely available drugs like statins, ACE inhibitors (ACEIs) angiotensin recepto...

Inaccurate self-reported data on medication exposure lead to less reliable study findings. From 2013 to 2015, we assessed the validity of information on medication use collected via a mailed medication inventory among 223 Women's Health Initiative participants who were members of a health-care delivery system. Self-reported information on medication use was compared with pharmacy records for st...

AIMS The impact on mortality outcomes of beta-blockers and calcium blockers in post-myocardial infarction (MI) has been suggested to be related to resting heart rate (HR) reduction. A meta-regression of randomized clinical trials was carried out to assess this relationship using weighted meta-regression of logarithm of odds ratio against absolute HR reduction. METHODS AND RESULTS Twenty-five ...