نتایج جستجو برای: mineralocorticoid receptor
تعداد نتایج: 591331 فیلتر نتایج به سال:
Aldosterone is one of the most essential hormones synthesized by adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) a newly discovered aldosterone receptor, which proposed to mediate non-genomic pathways while hormone simultaneously interacts with mineralocorticoid receptor. In contrast its cardio-protective role in postmenopausal women ...
M ineralocorticoid receptor (MR) antagonists are beneficial in heart failure and can reduce the incidence of sudden cardiac death, although side effects (including hyperkalemia) limit their widespread use. Establishing tissue-specific roles for MR signaling is critical to develop selective target therapies to achieve the beneficial effects of MR blockade without del-eterious side effects. MR si...
BACKGROUND The hypertensive syndrome of Apparent Mineralocorticoid Excess is caused by loss-of-function mutations in the gene encoding 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2), allowing inappropriate activation of the mineralocorticoid receptor by endogenous glucocorticoid. Hypertension is attributed to sodium retention in the distal nephron, but 11βHSD2 is also expressed in the brain....
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