It has been shown that αA-mini-chaperone, a peptide representing the chaperone binding site in αA-crystallin, prevents destabilized protein aggregation. αA-Mini-chaperone has been shown to form amyloid fibrils. This study was undertaken to improve the stability of αA-mini-chaperone while preserving its anti-aggregation activity by fusing the flexible and solvent-exposed C-terminal 164-173 regio...

Hand-drawn metro map illustrations often employ both internal and external labels in a way that they can assign enough information such as textual and image annotations to each landmark. Nonetheless, automatically tailoring the aesthetic layout of both textual and image labels together is still a challenging task, due to the complicated shape of the labeling space available around the metro net...

BACKGROUND The mini-mental state examination (MMSE) was adapted by individual countries according to their languages and cultures, though it has not been systematically compared. The objective of this study was to compare the linguistic and cultural variations of the MMSE used in various Asian countries. With this, we can analyze the strengths and weaknesses of the MMSE and consider using a com...

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BACKGROUND Psychiatric complaints are common among primary care patients, with depression and anxiety being the most frequent. Diagnosis of anxiety and depression can be difficult, potentially leading to over- as well as under-diagnosis. The diagnostic process can be facilitated by incorporating structured interviews as part of the assessment. One such instrument, the Mini-International Neurops...

INTRODUCTION The initial stability and survival rate of orthodontic mini-implants are highly dependent on the amount of cortical bone at their insertion site. In areas with limited bone availability, mini-plates are preferred to provide effective skeletal anchorage. The purpose of this paper was to present a new clinical technique for the insertion of mini-plates. METHODS In order to apply th...

OBJECTIVE To evaluate the validity and applicability of the Mini International Neuropsychiatric Interview (MINI) used by family medicine residents in primary health care (PHC) in Brazil. METHODS Training for administrating the MINI was given as part of a broad psychiatry education program. Interviews were held with 120 PHC patients who were at least 15 years old. MINI was administered by 25 r...

Orthodontic mini-implants were recently developed and have been widely used in clinics. However, loosening of mini-implants, as well as infection and swelling of mucosal tissue at the placement site, are often observed during orthodontic treatment. Thus, clinical indices are greatly needed for the safe use of orthodontic mini-implants. This article presents information on mini-implants and offe...